Stem-loop sequence hsa-mir-98

Accession

MI0000100 (change log)

Previous IDs

hsa-mir-98-X

Symbol

HGNC:MIR98

Description

Homo sapiens miR-98 stem-loop

Gene family

MIPF0000002; let-7

Literature search

137 open access papers mention hsa-mir-98
(563 sentences)

Stem-loop

   a    uc    -          u                 u    ---------      aggg 
5'  ggau  ugcu caugccaggg gagguaguaaguuguau guug         uggggu    a
    ||||  |||| |||||||||| ||||||||||||||||| ||||         ||||||    u
3'  cuua  acgg gugugguccc uuucaucauucaacaua caau         accccg    a
   a    -u    u          -                 u    agaagauua      gauu 

Deep sequencing

22596706 reads, 4.51e+04 reads per million, 159 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

This sequence is localised to chromosome X and was named mir-98-X in reference [1]. The predicted stem-loop precursor sequence is clearly related to let-7.

Genome context

• Coordinates (GRCh38; GCA_000001405.15): chrX: 53556223-53556341 [-]
• Overlapping transcripts:

  intergenic

Clustered miRNAs

< 10kb from hsa-mir-98

• hsa-let-7f-2: chrX: 53557192-53557274 [-]
• hsa-mir-98: chrX: 53556223-53556341 [-]

Database links

• EntrezGene:MIR98
• HGNC:MIR98
• RNAcentral:URS000075BF40_9606
• Rfam:let-7
• miRBase Tracker:MI0000100

Mature sequence hsa-miR-98-5p

• Accession: MIMAT0000096
• Previous IDs: hsa-miR-98
• Sequence: 22 - ugagguaguaaguuguauuguu - 43
• Deep sequencing: 22592846 reads, 159 experiments
• Evidence: experimental; cloned [1-3], SOLiD [4]
• Database links:
  • RNAcentral:URS00004E0808_9606
• Predicted targets:
  • TargetScanVert:hsa-miR-98-5p
  • miRDB:hsa-miR-98-5p
  • microrna.org:hsa-miR-98-5p

Mature sequence hsa-miR-98-3p

• Accession: MIMAT0022842
• Sequence: 80 - cuauacaacuuacuacuuuccc - 101
• Deep sequencing: 3413 reads, 126 experiments
• Evidence: experimental; SOLiD [4]
• Database links:
  • RNAcentral:URS0000122ED0_9606
• Predicted targets:
  • TargetScanVert:hsa-miR-98-3p
  • miRDB:hsa-miR-98-3p

References

1. PMID:11914277 "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs" Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G Genes Dev. 16:720-728(2002).
2. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
3. PMID:17616659 "Patterns of known and novel small RNAs in human cervical cancer" Lui WO, Pourmand N, Patterson BK, Fire A Cancer Res. 67:6031-6043(2007).
4. PMID:22282338 "Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs" Voellenkle C, Rooij Jv, Guffanti A, Brini E, Fasanaro P, Isaia E, Croft L, David M, Capogrossi MC, Moles A, Felsani A, Martelli F RNA. 18:472-484(2012).