Stem-loop sequence hsa-mir-30a

AccessionMI0000088 (change log)
Previous IDshsa-mir-30
Symbol HGNC:MIR30A
DescriptionHomo sapiens miR-30a stem-loop
Gene family MIPF0000005; mir-30
Literature search

486 open access papers mention hsa-mir-30a
(2440 sentences)

      a            uc           -----   a 
5' gcg cuguaaacaucc  gacuggaagcu     gug a
   ||| ||||||||||||  |||||||||||     |||  
3' cgu gacguuuguagg  cugacuuucgg     cac g
      c            --           guaga   c 
Get sequence
Deep sequencing
9652297 reads, 1.51e+04 reads per million, 159 experiments
Confidence Annotation confidence: high
Feedback: Do you believe this miRNA is real?

The mature sequences miR-30 [1] and miR-97 [2] appear to originate from the same precursor. Subsequent data confirm that both arms of the precursor appear to give rise to mature miRNA sequences (Pfeffer S, pers. comm.). Landgraf et al. later showed that the 5' product is the predominant one [5]. Related miRNAs are processed from the 5' arms of other precursor loci (mir-30b, MI0000441; mir-30c-1, MI0000736; mir-30c-2, MI0000254; mir-30d, MI0000255; mir-30e, MI0000749).

Genome context
Coordinates (GRCh38; GCA_000001405.15) Overlapping transcripts
chr6: 71403551-71403621 [-]
OTTHUMT00000041147 ; SMAP1-003; intron 1
OTTHUMT00000041148 ; SMAP1-004; intron 1
OTTHUMT00000041149 ; SMAP1-005; intron 1
OTTHUMT00000436306 ; RP11-160A9.3-001; exon 1
ENST00000370452 ; SMAP1-003; intron 1
ENST00000316999 ; SMAP1-004; intron 1
ENST00000370455 ; SMAP1-005; intron 1
ENST00000422334 ; SMAP1-201; intron 1
ENST00000572103 ; RP11-160A9.3-001; exon 1
Database links

Mature sequence hsa-miR-30a-5p

Accession MIMAT0000087
Previous IDshsa-miR-30a-5p;hsa-miR-30a

6 - 


 - 27

Get sequence
Deep sequencing8859499 reads, 159 experiments
Evidence experimental; cloned [2,4-6]
Database links
Predicted targets

Mature sequence hsa-miR-30a-3p

Accession MIMAT0000088
Previous IDshsa-miR-30a-3p;hsa-miR-30a*

47 - 


 - 68

Get sequence
Deep sequencing792782 reads, 159 experiments
Evidence experimental; cloned [1,4-5], Northern [1]
Database links
Predicted targets


PMID:11679670 "Identification of novel genes coding for small expressed RNAs" Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T Science. 294:853-858(2001).
PMID:11914277 "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs" Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G Genes Dev. 16:720-728(2002).
PMID:14573789 "Reduced accumulation of specific microRNAs in colorectal neoplasia" Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ Mol Cancer Res. 1:882-891(2003).
PMID:15325244 "Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells" Kasashima K, Nakamura Y, Kozu T Biochem Biophys Res Commun. 322:403-410(2004).
PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
PMID:17616659 "Patterns of known and novel small RNAs in human cervical cancer" Lui WO, Pourmand N, Patterson BK, Fire A Cancer Res. 67:6031-6043(2007).