Accession
MI0016786
Symbol
HGNC:
MIR4443
Description
Homo sapiens
hsa-mir-4443 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR4443 is a highly expressed microRNA in non-SC-EVs [PMC9800941]. A systematic review and meta-analysis revealed that upregulated MIR4443 is associated with better prognosis [PMC7827149]. Bioinformatics analysis identified METTL3 as a target gene of MIR4443 [PMC9617873]. In a study assessing the normalization of miRNA expression, MIR4443 was one of the miRNAs analyzed [PMC7035418]. However, the specificity of MIR4443 to Graves' disease was not investigated in patients with other autoimmune diseases [PMC5671953]. Additionally, MIR4443 has been found to inhibit cisplatin-induced ferroptosis by regulating AIFM2 expression in an m6A-dependent manner through METTL3 [PMC8572460]. In summary, MIR4443 is a highly expressed microRNA that has been associated with better prognosis and identified as a target gene for METTL3. It has also been analyzed in the context of miRNA normalization and its specificity to Graves' disease. Furthermore, its role in inhibiting cisplatin-induced ferroptosis has been elucidated.
Literature search
6 open access papers mention hsa-mir-4443
(63 sentences)
(63 sentences)
Sequence
4003
reads,
1181
reads per million, 80 experiments
ggugggggUUGGAGGCGUGGGUUUUagaaccuaucccuuucuagcccugagca
(.(.(((((((((((.(((((((....))))))).))..))))))))).).).
(.(.(((((((((((.(((((((....))))))).))..))))))))).).).
Structure
- g g -- C U g u ggggUUGGA GG GUGGGUU U | | ||||||||| || ||||||| c a ucccgaucu cc uauccaa a a g g uu c g
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr3: 48196564-48196616 [+]
Disease association
hsa-mir-4443 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-4443
| Accession | MIMAT0018961 |
| Description | Homo sapiens hsa-miR-4443 mature miRNA |
| Sequence | 9 - UUGGAGGCGUGGGUUUU - 25 |
| Evidence |
experimental
Illumina [1] |
| Database links |
|
| Predicted targets |
|
References
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