miRBase entry: hsa-mir-1260b

Stem-loop hsa-mir-1260b


Accession
MI0014197
Symbol
HGNC: MIR1260B
Description
Homo sapiens hsa-mir-1260b precursor miRNA
Gene family
MIPF0001381; mir-1260b

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR1260B is a microRNA molecule that has been found to have a close association with the Serin/Treonin-protein kinase family member of CHEK2 protein and cycline dependent kinase family members of CDK4 protein [PMC8504092]. It has been suggested that the expression of MIR1260B in peripheral blood lymphocytes may have prognostic significance and could be used as a bioindicator [PMC8504092]. The gene targets of MIR1260B, as detected from miRTarBase and TargetScan, have been found to interact at the protein level according to analysis performed using the String database [PMC8504092]. The significant expression of MIR1260B in peripheral blood lymphocytes has been demonstrated in ovarian cancer patients compared to healthy controls, suggesting its potential diagnostic significance in ovarian cancer [PMC8504092]. In a study using qPCR, TaqMan primers were used to analyze the expression of MIR1260B [PMC6144919]. It has also been shown that MIR1260B is involved in regulating SFRP1 expression in prostate cancer [PMC8869457]. Genistein treatment has been found to modulate the levels of various miRNAs, including MIR1260B, and affect cancer cell proliferation in prostate cancer [PMC7072821]. Furthermore, HNRNPK interacts with several genes including MIR1260B at the protein level [PMC9730017]. The abundance of MIR1260B in A-exosomes suggests its potential role in targeting specific mRNA and genes with functional consequences [PMC8176431]. In addition, miR1260a and MIR1260B were downregulated on day 7 compared to baseline samples on day 1 [PMC7169272]. Other miRNA genes located on 11q include MIR3166, miR3167, and MIR1260B, but their functions are unknown [PMC5492892]. Genistein treatment has been found to down-regulate MIR1260B expression in prostate cancer cells [PMC5068501].

Literature search
34 open access papers mention hsa-mir-1260b
(73 sentences)

Sequence

3936 reads, 91 reads per million, 95 experiments
ucuccguuuAUCCCACCACUGCCACCAUuauugcuacuguucagcaggugcugcugguggugauggugauagucuggugggggcggugg
.(.((((...(((((((((((.((((((((((((.......((((((...)))))))))))))))))).))))..))))))))))).).

Structure
u u    uuA       --    C            uacuguu      g 
 c ccgu   UCCCACC  ACUG CACCAUuauugc       cagcag  
 | ||||   |||||||  |||| ||||||||||||       |||||| u
 g ggcg   ggggugg  ugau gugguaguggug       gucguc  
g u    ---       uc    a            -------      g 


Annotation confidence Not enough data
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Genome context
chr11: 96341438-96341526 [+]

Disease association
hsa-mir-1260b is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-1260b

Accession MIMAT0015041
Description Homo sapiens hsa-miR-1260b mature miRNA
Sequence 10 - AUCCCACCACUGCCACCAU - 28
Evidence experimental
Illumina [1]
Database links
Predicted targets

References

  1. PubMed ID: 20300190
    Characterization of the Melanoma miRNAome by Deep Sequencing
    "Stark MS, Tyagi S, Nancarrow DJ, Boyle GM, Cook AL, Whiteman DC, Parsons PG, Schmidt C, Sturm RA, Hayward NK"
    "PLoS One (2010) 5:e9685