miRBase entry: hsa-mir-1246

Stem-loop hsa-mir-1246


Accession
MI0006381
Symbol
HGNC: MIR1246
Description
Homo sapiens hsa-mir-1246 precursor miRNA
Gene family
MIPF0000627; mir-1246

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR1246 is a type of microRNA that has been studied in relation to tumor invasion, lymph node metastasis, distant metastasis, and cancer stage. However, serum and urine levels of MIR1246 did not show any correlations with these factors (Table 2) [PMC7250935]. Despite this, MIR1246 has been found to have a specific target called early B cytokine 1 (EBF1) [PMC8258133]. It binds to the 3′UTR site of EBF1 and potentially regulates its expression. These findings suggest that MIR1246 may have a role in cancer progression through its interaction with EBF1. However, further research is needed to fully understand the functional significance of this interaction and its implications in cancer development and progression.

Literature search
83 open access papers mention hsa-mir-1246
(525 sentences)

Sequence

41973 reads, 1903 reads per million, 98 experiments
uguauccuugAAUGGAUUUUUGGAGCAGGaguggacaccugacccaaaggaaaucaauccauaggcuagcaau
(((..(((...((((((((((((..((((........))))..))))).......))))))))))...)))..

Structure
--   -au   ugA       -------     AG    agu 
  ugu   ccu   AUGGAUU       UUUGG  CAGG   g
  |||   |||   |||||||       |||||  ||||    
  acg   gga   uaccuaa       aaacc  gucc   g
ua   auc   ---       cuaaagg     ca    aca 


Annotation confidence Not enough data
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Genome context
chr2: 176600980-176601052 [-]

Disease association
hsa-mir-1246 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-1246

Accession MIMAT0005898
Description Homo sapiens hsa-miR-1246 mature miRNA
Sequence 11 - AAUGGAUUUUUGGAGCAGG - 29
Evidence experimental
Illumina [1]
Database links
Predicted targets

References

  1. PubMed ID: 18285502
    Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells
    "Morin RD, O'Connor MD, Griffith M, Kuchenbauer F, Delaney A, Prabhu AL, Zhao Y, McDonald H, Zeng T, Hirst M, Eaves CJ, Marra MA"
    "Genome Res (2008) 18:610-621