Stem-loop rno-mir-488

Accession

MI0006168

Description

Rattus norvegicus rno-mir-488 precursor miRNA

Gene family

MIPF0000318; mir-488

Literature search

5 open access papers mention rno-mir-488
(13 sentences)

Sequence

23741 reads, 64 reads per million, 343 experiments

aauccucucuCCCAGAUAAUGGCACUCUCAAacaaguuucuacauuguUUGAAAGGCUGUUUCUUGGUCagaagacucu
..((.(((..((.(((.((((((.((.((((((((((....)).)))))))).))))))))))).))..))).))....

Structure

--aa  c   cu  C   U      A  C        -  u 
    uc ucu  CC AGA AAUGGC CU UCAAacaa gu u
    || |||  || ||| |||||| || |||||||| ||  
    ag aga  GG UCU UUGUCG GA AGUUuguu ca c
ucuc  a   CU  U   -      -  A        a  u 

Annotation confidence High

Comments

The predominant miRNA cloned by Landgraf et al. has a 3' additional U residue, which is incompatible with the genome sequence [1].

Genome context

chr13: 76198593-76198671 [+]

Mature rno-miR-488-5p

• Accession: MIMAT0017320
• Description: Rattus norvegicus rno-miR-488-5p mature miRNA
• Sequence: 11 - CCCAGAUAAUGGCACUCUCAA - 31
• Evidence: experimental ; SOLiD [2]

Mature rno-miR-488-3p

• Accession: MIMAT0005341
• Description: Rattus norvegicus rno-miR-488-3p mature miRNA
• Sequence: 49 - UUGAAAGGCUGUUUCUUGGUC - 69
• Evidence: experimental ; cloned [1], SOLiD [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 20403161
   Small RNA expression and strain specificity in the rat
   Linsen SE, de Wit E, de Bruijn E, Cuppen E
   BMC Genomics (2010) 11:249