miRBase entry: hiv1-mir-N367

Stem-loop hiv1-mir-N367


Accession
MI0006104
Description
Human immunodeficiency virus 1 hiv1-mir-N367 precursor miRNA


Sequence

uuggcagaauuacacaccagggccagggaucagauauccACUGACCUUUGGAUGGUGCUUCAAgcuagua
(((((.(((.(((.((((((((.(((((((.....)))).))).)).)))).))))).)))..)))))..

Structure
--     -a   u   a  -    -  c   -    c 
  uuggc  gaa uac ca ccag gg cag ggau a
  |||||  ||| ||| || |||| || ||| |||| g
  gaucg  CUU GUG GU GGUU CC GUC ccua a
au     AA   C   -  A    U  A   A    u 


Annotation confidence Not enough data
Do you think this miRNA is real?
Comments
Extensive studies in two labs have failed to confirm the existence of any viral miRNAs in HIV [3,4]. This sequence should be considered at risk of deletion from future releases of miRBase.

Genome context
Unknown

Database links

Mature hiv1-miR-N367

Accession MIMAT0004478
Description Human immunodeficiency virus 1 hiv1-miR-N367 mature miRNA
Sequence 40 - ACUGACCUUUGGAUGGUGCUUCAA - 63
Evidence experimental
cloned [2], Northern [2]

References

  1. PubMed ID: 15782219
    Identification of microRNAs of the herpesvirus family
    "Pfeffer S, Sewer A, Lagos-Quintana M, Sheridan R, Sander C, Grasser FA, van Dyk LF, Ho CK, Shuman S, Chien M, Russo JJ, Ju J, Randall G, Lindenbach BD, Rice CM, Simon V, Ho DD, Zavolan M, Tuschl T"
    "Nat Methods (2005) 2:269-276

  2. PubMed ID: 15601474
    HIV-1 nef suppression by virally encoded microRNA
    Omoto S, Ito M, Tsutsumi Y, Ichikawa Y, Okuyama H, Brisibe EA, Saksena NK, Fujii YR
    Retrovirology (2004) 1:44

  3. PubMed ID: 15722536
    Regulation of human immunodeficiency virus 1 transcription by nef microRNA
    "Omoto S, Fujii YR"
    "J Gen Virol (2005) 86:751-755

  4. PubMed ID: 17855543
    Analysis of the interaction of primate retroviruses with the human RNA interference machinery
    "Lin J, Cullen BR"
    "J Virol (2007) 81:12218-12226