Stem-loop mmu-mir-488

Accession

MI0004633

Symbol

MGI: Mir488

Description

Mus musculus mmu-mir-488 precursor miRNA

Gene family

MIPF0000318; mir-488

Literature search

11 open access papers mention mmu-mir-488
(57 sentences)

Sequence

7680 reads, 117 reads per million, 39 experiments

uucgggugagagugagaauccucucuCCCAGAUAAUAGCACUCUCAAacaaguuuccauguuguUUGAAAGGCUGUUUCUUGGUCagaagacucucaauuucuucugga
((((((.((((.(((((.((.(((..((.(((.((((((.((.((((((((.........)))))))).))))))))))).))..))).)).))))).)))).))))))

Structure

      u    g     a  c   cu  C   U      A  C        guu 
uucggg gaga ugaga uc ucu  CC AGA AAUAGC CU UCAAacaa   u
|||||| |||| ||||| || |||  || ||| |||||| || ||||||||   c
aggucu cuuu acucu ag aga  GG UCU UUGUCG GA AGUUuguu   c
      u    a     c  a   CU  U   -      -  A        gua 

Annotation confidence High

Comments

The predominant miRNA cloned by Langraf et al. has a 3' terminal U residue, which is incompatible with the genome sequence [2].

Genome context

chr1: 158505625-158505733 [+]

Mature mmu-miR-488-5p

• Accession: MIMAT0003449
• Description: Mus musculus mmu-miR-488-5p mature miRNA
• Sequence: 27 - CCCAGAUAAUAGCACUCUCAA - 47
• Evidence: experimental ; Illumina [3-4]

Mature mmu-miR-488-3p

• Accession: MIMAT0003450
• Description: Mus musculus mmu-miR-488-3p mature miRNA
• Sequence: 65 - UUGAAAGGCUGUUUCUUGGUC - 85
• Evidence: experimental ; MPSS [1], cloned [2], Illumina [3-4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


3. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009


4. PubMed ID: 16582102
   The expression profile of microRNAs in mouse embryos
   "Mineno J, Okamoto S, Ando T, Sato M, Chono H, Izu H, Takayama M, Asada K, Mirochnitchenko O, Inouye M, Kato I"
   "Nucleic Acids Res (2006) 34:1765-1771