miRBase entry: hsa-mir-1185-2

Stem-loop hsa-mir-1185-2


Accession
MI0003821
Symbol
HGNC: MIR1185-2
Description
Homo sapiens hsa-mir-1185-2 precursor miRNA
Gene family
MIPF0000018; mir-154

Literature search
4 open access papers mention hsa-mir-1185-2
(4 sentences)

Sequence

2423 reads, 50 reads per million, 67 experiments
uuugguacuuaaagAGAGGAUACCCUUUGUAUGUUcacuugauuaauggcgaAUAUACAGGGGGAGACUCUCAUuugcguaucaaa
.(((((((.(((((((((..(.((((((((((((((.((........)).)))))))))))))))..))))).)))).))))))).

Structure
u       u    -     GA A              a  uga 
 uugguac uaaa gAGAG  U CCCUUUGUAUGUUc cu   u
 ||||||| |||| |||||  | |||||||||||||| ||    
 aacuaug guuU CUCUC  A GGGGGACAUAUAag gg   u
a       c    A     AG -              c  uaa 


Annotation confidence High
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Comments
This sequence was proposed as a miRNA candidate by Berezikov et al by RAKE analysis [1], and validated by cloning independently by Subramanian et al [2].

Genome context
chr14: 101044198-101044283 [+]
Clustered miRNAs
14 other miRNAs are < 10 kb from hsa-mir-1185-2
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-1185-2 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-1185-5p

Accession MIMAT0005798
Description Homo sapiens hsa-miR-1185-5p mature miRNA
Sequence 15 - AGAGGAUACCCUUUGUAUGUU - 35
Evidence experimental
cloned [2]
Database links
Predicted targets

Mature hsa-miR-1185-2-3p

Accession MIMAT0022713
Description Homo sapiens hsa-miR-1185-2-3p mature miRNA
Sequence 53 - AUAUACAGGGGGAGACUCUCAU - 74
Evidence not_experimental
Database links
Predicted targets

References

  1. PubMed ID: 16954537
    Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
    "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
    "Genome Res (2006) 16:1289-1298

  2. PubMed ID: 17922033
    MicroRNA expression signature of human sarcomas
    "Subramanian S, Lui WO, Lee CH, Espinosa I, Nielsen TO, Heinrich MC, Corless CL, Fire AZ, van de Rijn M"
    "Oncogene (2008) 27:2015-2026