Stem-loop hsa-mir-1224

Accession

MI0003764

Symbol

HGNC: MIR1224

Description

Homo sapiens hsa-mir-1224 precursor miRNA

Gene family

MIPF0000440; mir-1224

Literature search

22 open access papers mention hsa-mir-1224
(197 sentences)

Sequence

8393 reads, 77 reads per million, 49 experiments

GUGAGGACUCGGGAGGUGGaggguggugccgccggggccgggcgcuguuucagcucgcuucuccCCCCACCUCCUCUCUCCUCAG
.((((((...(((((((((..((((....))))((((..((((((((...))))..))))..)))))))))))))...)))))).

Structure

G      CUC         aggguggugccgcc    cc    --    u 
 UGAGGA   GGGAGGUGG              gggg  gggc  gcug  
 ||||||   |||||||||              ||||  ||||  |||| u
 ACUCCU   UCCUCCACC              CCcc  uucg  cgac  
G      CUC         --------------    uc    cu    u 

Annotation confidence Low

Comments

This sequence was identified as a miRNA candidate by Berezikov et al [1], and confirmed later by more extensive cloning [2].

Genome context

chr3: 184241405-184241489 [+]

Disease association

hsa-mir-1224 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-1224-5p

• Accession: MIMAT0005458
• Description: Homo sapiens hsa-miR-1224-5p mature miRNA
• Sequence: 1 - GUGAGGACUCGGGAGGUGG - 19
• Evidence: experimental ; RAKE [1], cloned [2]

Mature hsa-miR-1224-3p

• Accession: MIMAT0005459
• Description: Homo sapiens hsa-miR-1224-3p mature miRNA
• Sequence: 65 - CCCCACCUCCUCUCUCCUCAG - 85
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 16954537
   Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
   "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
   "Genome Res (2006) 16:1289-1298


2. PubMed ID: 17964270
   Mammalian mirtron genes
   "Berezikov E, Chung WJ, Willis J, Cuppen E, Lai EC"
   "Mol Cell (2007) 28:328-336