miRBase entry: ebv-mir-BART7

Stem-loop ebv-mir-BART7


Accession
MI0003729
Description
Epstein Barr virus ebv-mir-BART7 precursor miRNA
Gene family
MIPF0000328; mir-BART7


Sequence

uccaguguccugauCCUGGACCUUGACUAUGAAACAauucuaaaaaaaugCAUCAUAGUCCAGUGUCCAGGGacagugcacucgga
((((((((.(((.((((((((((.((((((((..((.((......)).))..)))))))).)).)))))))).))).))))).)))

Structure
   -     c   a        -  U        AA  a  cu 
ucc agugu cug uCCUGGAC CU GACUAUGA  CA uu  a
||| ||||| ||| |||||||| || ||||||||  || ||   
agg ucacg gac GGGACCUG GA CUGAUACU  gu aa  a
   c     u   a        U  C        AC  a  aa 


Annotation confidence Not enough data
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Comments
mir-BART7 was discovered independently by two groups. Cai et al mapped the ends of the mature sequence by cloning [1]. Grundhoff et al confirmed that the 3' arm gives rise to a mature miRNA product, but didnot experimentally determine the extents of that product [2]. This sequence is misnamed miR-BART11 in [2].

Genome context
HHV507799: 146425-146510 [+]
Clustered miRNAs
21 other miRNAs are < 10 kb from ebv-mir-BART7
Name Accession Chromosome Start End Strand Confidence




Disease association
ebv-mir-BART7 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature ebv-miR-BART7-5p

Accession MIMAT0004815
Description Epstein Barr virus ebv-miR-BART7-5p mature miRNA
Sequence 15 - CCUGGACCUUGACUAUGAAACA - 36
Evidence experimental
cloned [3]

Mature ebv-miR-BART7-3p

Accession MIMAT0003416
Description Epstein Barr virus ebv-miR-BART7-3p mature miRNA
Sequence 51 - CAUCAUAGUCCAGUGUCCAGGG - 72
Evidence experimental
cloned [1,3], array [2], Northern [2]

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 16557291
    Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed
    Cai X, Schäfer A, Lu S, Bilello JP, Desrosiers RC, Edwards R, Raab-Traub N, Cullen BR
    PLoS Pathog (2006) 2:e23

  3. PubMed ID: 16540699
    A combined computational and microarray-based approach identifies novel microRNAs encoded by human gamma-herpesviruses
    "Grundhoff A, Sullivan CS, Ganem D"
    "RNA (2006) 12:733-750