miRBase entry: hsa-mir-589

Stem-loop hsa-mir-589


Accession
MI0003599
Symbol
HGNC: MIR589
Description
Homo sapiens hsa-mir-589 precursor miRNA
Gene family
MIPF0000496; mir-589

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR589 is a miRNA gene located in the chromosomal region 7p22, which is prone to gaps and breaks in various cancers [PMC3634031]. In a study comparing different populations, it was found that MIR589 was the only differentially methylated and expressed miRNA in individuals of European ancestry [PMC8453167]. Several other miRNAs, including MIR589, have been identified as overexpressed in breast cancer and have potential applications in diagnosis, prognosis, and therapeutic studies [PMC4508501]. In an experiment investigating the effect of TGFβ1 on MIR589 expression, it was observed that TGFβ1 treatment decreased the expression of MIR589 [PMC3479401]. The decreased expression of MIR589 was also observed in human peritoneal mesothelial cells (HPMCs) isolated from peritoneal dialysis patients and HMrSV5 cells treated with TGFβ1 [PMC3479401]. Additionally, a study on IFN-γ stimulation identified MIR589 as one of the top 10 upregulated miRNAs [PMC8010072]. Overall, these findings highlight the potential role of MIR589 in cancer development and progression.

Literature search
15 open access papers mention hsa-mir-589
(37 sentences)

Sequence

5972 reads, 91 reads per million, 108 experiments
uccagccugugcccagcagccccUGAGAACCACGUCUGCUCUGAGcuggguacugccuguUCAGAACAAAUGCCGGUUCCCAGAcgcugccagcuggcc
.(((((.((......(((((..(((.(((((.(((.((.(((((((.((......)).))))))).)).)))..))))).)))..))))))))))))..

Structure
-u     c  ugccca     cc   A     -A   C  C       u  gu 
  ccagc ug      gcagc  cUG GAACC  CGU UG UCUGAGc gg  a
  ||||| ||      |||||  ||| |||||  ||| || ||||||| ||   
  ggucg ac      cgucg  GAC CUUGG  GUA AC AGACUug cc  c
cc     -  ------     cA   C     CC   A  A       u  gu 


Annotation confidence High
Do you think this miRNA is real?

Genome context
chr7: 5495819-5495917 [-]

Disease association
hsa-mir-589 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-589-5p

Accession MIMAT0004799
Description Homo sapiens hsa-miR-589-5p mature miRNA
Sequence 24 - UGAGAACCACGUCUGCUCUGAG - 45
Evidence experimental
cloned [2]
Database links
Predicted targets

Mature hsa-miR-589-3p

Accession MIMAT0003256
Description Homo sapiens hsa-miR-589-3p mature miRNA
Sequence 61 - UCAGAACAAAUGCCGGUUCCCAGA - 84
Evidence experimental
SAGE [1]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 16505370
    The colorectal microRNAome
    "Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE"
    "Proc Natl Acad Sci U S A (2006) 103:3687-3692