miRBase entry: hsa-mir-506

Stem-loop hsa-mir-506


Accession
MI0003193
Symbol
HGNC: MIR506
Description
Homo sapiens hsa-mir-506 precursor miRNA
Gene family
MIPF0000130; mir-506

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR506 is a microRNA that is upregulated in the intrahepatic bile duct of patients with primary biliary cholangitis (PBC) and regulates the secretion of biliary epithelial cells (BECs) by targeting AE2 [PMC8147992]. However, a specific interaction between endogenously expressed miR124 and MIR506 does not account for the decrease in expression level in astrocytic cells [PMC5476465]. In pancreatic ductal adenocarcinoma (PDAC), the replacement of MIR506 induces autophagy [PMC9312874]. Overexpression of MIR506 leads to an increase in BCL2 gene expression [PMC7477680]. Low expression levels of MIR506 may contribute to higher levels of CDK6 and CTNNB1 mRNAs in adrenocortical carcinomas (ACCs) [PMC5764399]. MIR506 is part of a group of noncoding RNAs, including miR-34, miR-155, and miR-21, that regulate the reactive oxygen species-cancer axis in various malignancies, including lung cancer [PMC9442502]. In T-cell acute lymphoblastic leukemia (TALL), transfection with MIR506 leads to an increase in its own expression [PMC7477680]. In wheat, 58 miRNAs have been discovered, including MIR506, which targets AB182944 encoding a knox1b homeobox protein [PMC5360763]. Finally, PCR analysis using specific primers reveals binding sites for SOX9 and TEAD1 on the promoters of SOX9 and MIR506 genes respectively [PMC6756096].

Literature search
61 open access papers mention hsa-mir-506
(334 sentences)

Sequence

12157 reads, 403 reads per million, 25 experiments
gccaccaccaucagccauacuauguguagugccuUAUUCAGGAAGGUGUUACUUAAuagauuaauauuugUAAGGCACCCUUCUGAGUAGAguaaugugcaacauggacaacauuugugguggc
((((((((...........(((((((((.(((.((((((((((.(((((..((((.(((((....)))))))))))))).)))))))))).)))...))).)))))).........))))))))

Structure
        caucagccaua      -   --g   c          A     UA    A     u 
gccaccac           cuaugu gua   ugc uUAUUCAGGA GGUGU  CUUA uagau a
||||||||           |||||| |||   ||| |||||||||| |||||  |||| |||||  
cgguggug           gguaca cgu   aug GAUGAGUCUU CCACG  GAAU guuua a
        --uuuacaaca      a   gua   A          C     --    -     u 


Annotation confidence High
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Genome context
chrX: 147230720-147230843 [-]
Clustered miRNAs
3 other miRNAs are < 10 kb from hsa-mir-506
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-506 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-506-3p

Accession MIMAT0002878
Description Homo sapiens hsa-miR-506-3p mature miRNA
Sequence 71 - UAAGGCACCCUUCUGAGUAGA - 91
Evidence experimental
array-cloned [1]
Database links
Predicted targets

Mature hsa-miR-506-5p

Accession MIMAT0022701
Description Homo sapiens hsa-miR-506-5p mature miRNA
Sequence 35 - UAUUCAGGAAGGUGUUACUUAA - 56
Evidence not_experimental
Database links
Predicted targets

References

  1. PubMed ID: 15965474
    Identification of hundreds of conserved and nonconserved human microRNAs
    "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
    "Nat Genet (2005) 37:766-770