miRBase entry: hsa-mir-499a

Stem-loop hsa-mir-499a


Accession
MI0003183
Symbol
HGNC: MIR499A
Description
Homo sapiens hsa-mir-499a precursor miRNA
Gene family
MIPF0000173; mir-499

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

In our study, we failed to observe an association of the polymorphism in the rs3746444 polymorphism of MIR499A and the miR-499a expression [1]. MIR499A expression was also examined in Ad-HBV or Ad-GFP infected HepG2 cells [2]. In addition, we explored the target gene of MIR499A to disclose the underlying mechanism of MIR499A functions in HCC [2].

References:
1. Zhang, Y., Zhang, Y., Li, X., Zhang, X., Liang, H., Liang, W., ... & Wang, Y. (2021). The association between polymorphisms in microRNA genes and hepatocellular carcinoma risk: a meta-analysis. BMC cancer, 21(1), 1-12. [PMC8514969]
2. Wang, Y., Tohme, S., & Gao, Z. (2014). MicroRNA: a new therapeutic target for human hepatocellular carcinoma. Gastroenterology research and practice 2014. [PMC4207808]

Literature search
136 open access papers mention hsa-mir-499a
(778 sentences)

Sequence

67990 reads, 1643 reads per million, 101 experiments
gcccuguccccugugccuugggcgggcggcugUUAAGACUUGCAGUGAUGUUUaacuccucuccacgugAACAUCACAGCAAGUCUGUGCUgcuucccgucccuacgcugccugggcagggu
(((((((((.....((...(((((((.(((.((..((((((((.((((((((((.............)))))))))).))))))))..)).))).)))).)))...)).....)))))))))

Structure
         ccugu  cuu   -    c   u  UA        A          acucc 
gcccugucc     gc   ggg cggg ggc gU  AGACUUGC GUGAUGUUUa     u
|||||||||     ||   ||| |||| ||| ||  |||||||| ||||||||||     c
ugggacggg     cg   ccc gccc ucg CG  UCUGAACG CACUACAAgu     u
         uccgu  cau   u    u   U  UG        A          gcacc 


Annotation confidence High
Do you think this miRNA is real?
Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context
chr20: 34990376-34990497 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-499a
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-499a is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-499a-5p

Accession MIMAT0002870
Description Homo sapiens hsa-miR-499a-5p mature miRNA
Sequence 33 - UUAAGACUUGCAGUGAUGUUU - 53
Evidence experimental
array-cloned [1], cloned [2]
Database links
Predicted targets

Mature hsa-miR-499a-3p

Accession MIMAT0004772
Description Homo sapiens hsa-miR-499a-3p mature miRNA
Sequence 70 - AACAUCACAGCAAGUCUGUGCU - 91
Evidence experimental
cloned [2]

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 15965474
    Identification of hundreds of conserved and nonconserved human microRNAs
    "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
    "Nat Genet (2005) 37:766-770