Accession
MI0003153
Symbol
HGNC:
MIR523
Description
Homo sapiens
hsa-mir-523 precursor miRNA
Gene family
MIPF0000020;
mir-515
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR523 is a miRNA gene that is part of the C19MC miRNA gene cluster on chromosome 19 [PMC6193703]. In breast invasive carcinoma, the expression of MIR523 was not significantly different between the CAA and control groups when using a variable threshold, but became significantly different when using a fixed threshold [PMC7157974]. Additionally, MIR523 was close to being significantly different in other analyses [PMC7157974]. However, the targets for MIR523 and other miRNAs in the C19MC cluster could not be predicted due to limited available sequences in databases [PMC2394755]. In hepatocellular carcinoma (HCC), the expression of MIR523 and other C19MC miRNA genes was analyzed using TCGA miRNA-seq dataset and matched to HCC-iCluster RNA-seq data set to create an integrated dataset [PMC7378193]. Furthermore, MIR523 is part of a subset of miRNAs on chromosome 19 that have been associated with stem cell biology and tumorigenesis [PMC8508841]. References: - [PMC6193703]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193703/ - [PMC7157974]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157974/ - [PMC2394755]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394755/ - [PMC7378193]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378193/ - [PM8508841]: https://www.ncbi.nlm.nih.gov/pmc/articles/PM8508841/
Literature search
4 open access papers mention hsa-mir-523
(10 sentences)
(10 sentences)
Sequence
107
reads,
16
reads per million, 19 experiments
ucucaugcugugaccCUCUAGAGGGAAGCGCUUUCUGuugucugaaagaaaaGAACGCGCUUCCCUAUAGAGGGUuacccuuugaga
(((((....(((((((((((.((((((((((.((((....(((...)))..)))).)))))))))).)))))))))))....)))))
(((((....(((((((((((.((((((((((.((((....(((...)))..)))).)))))))))).)))))))))))....)))))
Structure
ugcu G U Guug g
ucuca gugaccCUCUA AGGGAAGCGC UUCU ucu
||||| ||||||||||| |||||||||| |||| ||| a
agagu cauUGGGAGAU UCCCUUCGCG AAGa aga
uucc A C --aa a
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr19: 53698385-53698471 [+]
Clustered miRNAs
10 other miRNAs are < 10 kb from hsa-mir-523
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-523 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-523-5p
| Accession | MIMAT0005449 |
| Description | Homo sapiens hsa-miR-523-5p mature miRNA |
| Sequence | 16 - CUCUAGAGGGAAGCGCUUUCUG - 37 |
| Evidence |
experimental
array-cloned [1], cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-523-3p
| Accession | MIMAT0002840 |
| Description | Homo sapiens hsa-miR-523-3p mature miRNA |
| Sequence | 53 - GAACGCGCUUCCCUAUAGAGGGU - 75 |
| Evidence |
experimental
array-cloned [1], cloned [2] |
References
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