Stem-loop hsa-mir-519b

Accession

MI0003151

Symbol

HGNC: MIR519B

Description

Homo sapiens hsa-mir-519b precursor miRNA

Gene family

MIPF0000020; mir-515

Literature search

21 open access papers mention hsa-mir-519b
(100 sentences)

Sequence

180 reads, 19 reads per million, 25 experiments

caugcugugaccCUCUAGAGGGAAGCGCUUUCUGuugucugaaagaaaagAAAGUGCAUCCUUUUAGAGGUUuacuguuug
((.((.((((.((((((((((((.(((((((((....(((...)))..))))))))).)))))))))))).)))).)).))

Structure

  u  u    c            A         Guug   g 
ca gc guga cCUCUAGAGGGA GCGCUUUCU    ucu  
|| || |||| |||||||||||| |||||||||    ||| a
gu ug cauU GGAGAUUUUCCU CGUGAAAga    aga  
  u  u    U            A         --aa   a 

Annotation confidence High

Comments

The 5' arm of this precursor expresses a product related to miR-526 (previously named miR-526c here). Landgraf et al. confirm mature miRNA expression from both arms of the precursor [2], leading to the -5p, -3p designations. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chr19: 53695213-53695293 [+]

Clustered miRNAs

9 other miRNAs are < 10 kb from hsa-mir-519b

Disease association

hsa-mir-519b is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-519b-5p

• Accession: MIMAT0005454
• Description: Homo sapiens hsa-miR-519b-5p mature miRNA
• Sequence: 13 - CUCUAGAGGGAAGCGCUUUCUG - 34
• Evidence: experimental ; array-cloned [1], cloned [2]

Mature hsa-miR-519b-3p

• Accession: MIMAT0002837
• Description: Homo sapiens hsa-miR-519b-3p mature miRNA
• Sequence: 51 - AAAGUGCAUCCUUUUAGAGGUU - 72
• Evidence: experimental ; array-cloned [1], cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15965474
   Identification of hundreds of conserved and nonconserved human microRNAs
   "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
   "Nat Genet (2005) 37:766-770