Stem-loop hsa-mir-489

Accession

MI0003124

Symbol

HGNC: MIR489

Description

Homo sapiens hsa-mir-489 precursor miRNA

Gene family

MIPF0000111; mir-489

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR489 is a microRNA that has been identified in various studies as playing a role in different biological processes. It has been found to be differentially expressed in paired samples and shares similar regulatory trends with other miRNAs [PMC3398046]. MIR489 is necessary for maintaining the quiescent state of satellite cells by post-transcriptionally repressing the oncogene Dek [PMC6303387]. It has also been implicated in the regulation of quiescence in MuSCs [PMC9715903]. MIR489 has been shown to be downregulated in certain conditions, such as cardiac hypertrophy, where it is regulated by the lncRNA cardiac hypertrophy-related factor (chrf) [PMC7123062]. Additionally, MIR489 has been identified as a positive modulator of adult stem cell quiescence and is involved in the post-transcriptional suppression of the oncogene Dek [PMC6446479]. In breast cancer cell lines, overexpression of MIR489 leads to down-regulation of HER2 [PMC4951289]. Downregulation of miR200c and MIR489 has been associated with better prognosis, while upregulation of miR484 and miR4443 is associated with better prognosis [PMC7827149]. Furthermore, targeting MIR489 may have therapeutic potential for certain conditions such as kidney ischemia and cardiac hypertrophy [PMC8001091] [PMC6562440] . However, it should be noted that deletion or knockout of certain genes may not necessarily affect the expression or presence of intronic MIR489 or other miRNAs such as miR208.

Literature search

46 open access papers mention hsa-mir-489
(424 sentences)

Sequence

667 reads, 17 reads per million, 43 experiments

guggcagcuugguGGUCGUAUGUGUGACGCCAUUUacuugaaccuuuaggaGUGACAUCACAUAUACGGCAGCuaaacugcuac
(((((((.(((((.(((((((((((((.(.((((..(((((....))))))))).).))))))))))))).))))).)))))))

Structure

       c     G             C C    Ua     a 
guggcag uuggu GUCGUAUGUGUGA G CAUU  cuuga c
||||||| ||||| ||||||||||||| | ||||  |||||  
caucguc aauCG CGGCAUAUACACU C GUGa  ggauu c
       a     A             A A    --     u 

Annotation confidence Not enough data

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2]. The 5' end of the miRNA may be offset with respect to previous annotations.

Genome context

chr7: 93483936-93484019 [-]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-489

Disease association

hsa-mir-489 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-489-3p

• Accession: MIMAT0002805
• Description: Homo sapiens hsa-miR-489-3p mature miRNA
• Sequence: 52 - GUGACAUCACAUAUACGGCAGC - 73
• Evidence: experimental ; array-cloned [1], cloned [2], Illumina [3]

Mature hsa-miR-489-5p

• Accession: MIMAT0026605
• Description: Homo sapiens hsa-miR-489-5p mature miRNA
• Sequence: 14 - GGUCGUAUGUGUGACGCCAUUU - 35
• Evidence: experimental ; Illumina [3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15965474
   Identification of hundreds of conserved and nonconserved human microRNAs
   "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
   "Nat Genet (2005) 37:766-770


3. PubMed ID: 23034410
   Birth and expression evolution of mammalian microRNA genes
   "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
   "Genome Res (2013) 23:34-45