Stem-loop mml-mir-18a

Accession

MI0003002

Description

Macaca mulatta mml-mir-18a precursor miRNA

Gene family

MIPF0000001; mir-17

Literature search

3 open access papers mention mml-mir-18a
(7 sentences)

Sequence

1957 reads, 31 reads per million, 9 experiments

uguucUAAGGUGCAUCUAGUGCAGAUAgugaaguagauuagcaucuACUGCCCUAAGUGCUCCUUCUGGCa
((((..((((.((((.(((.((((.(((((..(.....)..)).))))))).))).)))).))))..))))

Structure

    cU    U    C   U    A   -  aa u 
uguu  AAGG GCAU UAG GCAG UAg ug  g a
||||  |||| |||| ||| |||| ||| ||  | g
aCGG  UUCC CGUG AUC CGUC Auc ac  u a
    UC    U    A   C    -   u  ga u 

Annotation confidence High

Comments

Berezikov et al. used primers designed from human miRNA gene flanking sequence to amplify miRNA precursor regions in primates [1]. The expression of the mature miRNA was not validated.

Genome context

chr17: 73096253-73096323 [+]

Clustered miRNAs

5 other miRNAs are < 10 kb from mml-mir-18a

Mature mml-miR-18a-5p

• Accession: MIMAT0002702
• Description: Macaca mulatta mml-miR-18a-5p mature miRNA
• Sequence: 6 - UAAGGUGCAUCUAGUGCAGAUA - 27
• Evidence: experimental ; Illumina [2]

Mature mml-miR-18a-3p

• Accession: MIMAT0026595
• Description: Macaca mulatta mml-miR-18a-3p mature miRNA
• Sequence: 47 - ACUGCCCUAAGUGCUCCUUCUGGC - 70
• Evidence: experimental ; Illumina [2]

References

1. PubMed ID: 15652478
   Phylogenetic shadowing and computational identification of human microRNA genes
   "Berezikov E, Guryev V, van de Belt J, Wienholds E, Plasterk RH, Cuppen E"
   "Cell (2005) 120:21-24


2. PubMed ID: 23034410
   Birth and expression evolution of mammalian microRNA genes
   "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
   "Genome Res (2013) 23:34-45