miRBase entry: mml-mir-99a

Stem-loop mml-mir-99a


Accession
MI0002702
Description
Macaca mulatta mml-mir-99a precursor miRNA
Gene family
MIPF0000033; mir-10


Sequence

216871 reads, 1666 reads per million, 9 experiments
cccauuggcauaAACCCGUAGAUCCGAUCUUGUGgugaaguggaccgcacAAGCUCGCUUCUAUGGGUCUGugucagugug
..((((((((((.(((((((((..(((.((((((.((........)))))))).)))..))))))))).))))))))))..

Structure
cc          A         UC   U      g  aag 
  cauuggcaua ACCCGUAGA  CGA CUUGUG ug   u
  |||||||||| |||||||||  ||| |||||| ||    
  gugacuguGU UGGGUAUCU  GCU GAAcac gc   g
gu          C         UC   C      -  cag 


Annotation confidence High
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Comments
Berezikov et al. used primers designed from human miRNA gene flanking sequence to amplify miRNA precursor regions in primates [2]. The expression of this mature miRNA was validated by Miska et al [1].

Genome context
chr3: 31071139-31071219 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from mml-mir-99a
Name Accession Chromosome Start End Strand Confidence




Database links

Mature mml-miR-99a-5p

Accession MIMAT0002410
Description Macaca mulatta mml-miR-99a-5p mature miRNA
Sequence 13 - AACCCGUAGAUCCGAUCUUGUG - 34
Evidence experimental
cloned [1], Illumina [3]
Database links
Predicted targets

Mature mml-miR-99a-3p

Accession MIMAT0026579
Description Macaca mulatta mml-miR-99a-3p mature miRNA
Sequence 51 - AAGCUCGCUUCUAUGGGUCUG - 71
Evidence experimental
Illumina [3]

References

  1. PubMed ID: 15345052
    Microarray analysis of microRNA expression in the developing mammalian brain
    Miska EA, Alvarez-Saavedra E, Townsend M, Yoshii A, Sestan N, Rakic P, Constantine-Paton M, Horvitz HR
    Genome Biol (2004) 5:R68

  2. PubMed ID: 15652478
    Phylogenetic shadowing and computational identification of human microRNA genes
    "Berezikov E, Guryev V, van de Belt J, Wienholds E, Plasterk RH, Cuppen E"
    "Cell (2005) 120:21-24

  3. PubMed ID: 23034410
    Birth and expression evolution of mammalian microRNA genes
    "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
    "Genome Res (2013) 23:34-45