miRBase entry: mml-mir-21

Stem-loop mml-mir-21


Accession
MI0002621
Description
Macaca mulatta mml-mir-21 precursor miRNA
Gene family
MIPF0000060; mir-21

Literature search
7 open access papers mention mml-mir-21
(102 sentences)

Sequence

1927905 reads, 16314 reads per million, 9 experiments
ugucgggUAGCUUAUCAGACUGAUGUUGAcuguugaaucucauggCAACACCAGUCGAUGGGCUGUCugaca
((((((((((((((((.(((((.(((((.((((.((...))))))))))).)))))))))))))))))))))

Structure
                A     A     A    u  a 
ugucgggUAGCUUAUC GACUG UGUUG cugu ga  
|||||||||||||||| ||||| ||||| |||| || u
acaguCUGUCGGGUAG CUGAC ACAAC ggua cu  
                -     C     -    -  c 


Annotation confidence High
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Comments
Berezikov et al. used primers designed from human miRNA gene flanking sequence to amplify miRNA precursor regions in primates [1]. The expression of the mature miRNA was not validated.

Genome context
chr16: 53341909-53341980 [+]

Database links

Mature mml-miR-21-5p

Accession MIMAT0002320
Description Macaca mulatta mml-miR-21-5p mature miRNA
Sequence 8 - UAGCUUAUCAGACUGAUGUUGA - 29
Evidence experimental
Illumina [2]
Database links
Predicted targets

Mature mml-miR-21-3p

Accession MIMAT0026573
Description Macaca mulatta mml-miR-21-3p mature miRNA
Sequence 46 - CAACACCAGUCGAUGGGCUGUC - 67
Evidence experimental
Illumina [2]

References

  1. PubMed ID: 15652478
    Phylogenetic shadowing and computational identification of human microRNA genes
    "Berezikov E, Guryev V, van de Belt J, Wienholds E, Plasterk RH, Cuppen E"
    "Cell (2005) 120:21-24

  2. PubMed ID: 23034410
    Birth and expression evolution of mammalian microRNA genes
    "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
    "Genome Res (2013) 23:34-45