Stem-loop mml-mir-188

Accession

MI0002608

Description

Macaca mulatta mml-mir-188 precursor miRNA

Gene family

MIPF0000113; mir-188

Sequence

653 reads, 10 reads per million, 9 experiments

ugcucccucucucaCAUCCCUUGCAUGGUGGAGGGUgagcuuuaugaaaaccccUCCCACAUGCAGGGUUUGCAggauggugagcc
.((((((..(((..((..(((((((((..((((((....(.....).....))))))..)))))))))..))..))).)).)))).

Structure

u    -  uc   ca  UC         GU      -Ugag u 
 gcuc cc  ucu  CA  CCUUGCAUG  GGAGGG     c u
 |||| ||  |||  ||  |||||||||  ||||||     | u
 cgag gg  agg  GU  GGGACGUAC  CCUccc     g a
c    u  -u   AC  UU         AC      caaaa u 

Annotation confidence High

Comments

Berezikov et al. used primers designed from human miRNA gene flanking sequence to amplify miRNA precursor regions in primates [1]. The expression of the mature miRNA was not validated.

Genome context

chrX: 50008578-50008663 [+]

Clustered miRNAs

5 other miRNAs are < 10 kb from mml-mir-188

Mature mml-miR-188-5p

• Accession: MIMAT0002307
• Description: Macaca mulatta mml-miR-188-5p mature miRNA
• Sequence: 15 - CAUCCCUUGCAUGGUGGAGGGU - 36
• Evidence: experimental ; Illumina [2]

Mature mml-miR-188-3p

• Accession: MIMAT0026571
• Description: Macaca mulatta mml-miR-188-3p mature miRNA
• Sequence: 55 - UCCCACAUGCAGGGUUUGCA - 74
• Evidence: experimental ; Illumina [2]

References

1. PubMed ID: 15652478
   Phylogenetic shadowing and computational identification of human microRNA genes
   "Berezikov E, Guryev V, van de Belt J, Wienholds E, Plasterk RH, Cuppen E"
   "Cell (2005) 120:21-24


2. PubMed ID: 23034410
   Birth and expression evolution of mammalian microRNA genes
   "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
   "Genome Res (2013) 23:34-45