Stem-loop mml-mir-127

Accession

MI0002582

Description

Macaca mulatta mml-mir-127 precursor miRNA

Gene family

MIPF0000080; mir-127

Sequence

163492 reads, 1087 reads per million, 9 experiments

ugugaucacugucuccagccugcUGAAGCUCAGAGGGCUCUGAUUcagaaagaucaUCGGAUCCGUCUGAGCUUGGCUggucggaagucuccucauc
.((((..(((...(((.(((.(((.(((((((((.((.((((((((.....))..)))))).)).)))))))))))).))).))))))....)))).

Structure

u    --uc   guc   a   u   G         G  C      --  a 
 guga    acu   ucc gcc gcU AAGCUCAGA GG UCUGAU  Uc g
 ||||    |||   ||| ||| ||| ||||||||| || ||||||  || a
 uacu    uga   agg ugg CGG UUCGAGUCU CC AGGCUa  ag a
c    ccuc   ---   c   U   -         G  U      cu  a 

Annotation confidence High

Comments

Berezikov et al. used primers designed from human miRNA gene flanking sequence to amplify miRNA precursor regions in primates [1]. The expression of the mature miRNA was not validated.

Genome context

chr7: 163217177-163217273 [+]

Clustered miRNAs

6 other miRNAs are < 10 kb from mml-mir-127

Mature mml-miR-127-3p

• Accession: MIMAT0002281
• Description: Macaca mulatta mml-miR-127-3p mature miRNA
• Sequence: 57 - UCGGAUCCGUCUGAGCUUGGCU - 78
• Evidence: experimental ; Illumina [2]

Mature mml-miR-127-5p

• Accession: MIMAT0026570
• Description: Macaca mulatta mml-miR-127-5p mature miRNA
• Sequence: 24 - UGAAGCUCAGAGGGCUCUGAUU - 45
• Evidence: experimental ; Illumina [2]

References

1. PubMed ID: 15652478
   Phylogenetic shadowing and computational identification of human microRNA genes
   "Berezikov E, Guryev V, van de Belt J, Wienholds E, Plasterk RH, Cuppen E"
   "Cell (2005) 120:21-24


2. PubMed ID: 23034410
   Birth and expression evolution of mammalian microRNA genes
   "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
   "Genome Res (2013) 23:34-45