miRBase entry: mml-mir-145

Stem-loop mml-mir-145


Accession
MI0002558
Description
Macaca mulatta mml-mir-145 precursor miRNA
Gene family
MIPF0000079; mir-145

Literature search
3 open access papers mention mml-mir-145
(10 sentences)

Sequence

39572 reads, 335 reads per million, 9 experiments
caccuuguccucacgGUCCAGUUUUCCCAGGAAUCCCUUaaaugcuaagauggGGAUUCCUGGAAAUACUGUUCUUgaggucaugguu
.(((.((.(((((.((..((((.((.((((((((((((.............)))))))))))).)).))))..))))))).)).))).

Structure
c   u  u     c  UC    U  C            Uaaau 
 acc ug ccuca gG  CAGU UU CCAGGAAUCCCU     g
 ||| || ||||| ||  |||| || ||||||||||||     c
 ugg ac ggagU UC  GUCA AA GGUCCUUAGGgg     u
u   u  u     -  UU    U  A            uagaa 


Annotation confidence High
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Comments
Berezikov et al. used primers designed from human miRNA gene flanking sequence to amplify miRNA precursor regions in primates [2]. The expression of this mature miRNA was validated by Miska et al [1].

Genome context
chr6: 147552171-147552258 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from mml-mir-145
Name Accession Chromosome Start End Strand Confidence




Database links

Mature mml-miR-145-5p

Accession MIMAT0002266
Description Macaca mulatta mml-miR-145-5p mature miRNA
Sequence 16 - GUCCAGUUUUCCCAGGAAUCCCUU - 39
Evidence experimental
cloned [1], Illumina [3]
Database links
Predicted targets

Mature mml-miR-145-3p

Accession MIMAT0026568
Description Macaca mulatta mml-miR-145-3p mature miRNA
Sequence 54 - GGAUUCCUGGAAAUACUGUUCUU - 76
Evidence experimental
Illumina [3]
Database links
Predicted targets

References

  1. PubMed ID: 15345052
    Microarray analysis of microRNA expression in the developing mammalian brain
    Miska EA, Alvarez-Saavedra E, Townsend M, Yoshii A, Sestan N, Rakic P, Constantine-Paton M, Horvitz HR
    Genome Biol (2004) 5:R68

  2. PubMed ID: 15652478
    Phylogenetic shadowing and computational identification of human microRNA genes
    "Berezikov E, Guryev V, van de Belt J, Wienholds E, Plasterk RH, Cuppen E"
    "Cell (2005) 120:21-24

  3. PubMed ID: 23034410
    Birth and expression evolution of mammalian microRNA genes
    "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
    "Genome Res (2013) 23:34-45