Stem-loop sequence hsa-mir-376b

Accession

MI0002466 (change log)

Symbol

HGNC:MIR376B

Description

Homo sapiens miR-376b stem-loop

Gene family

MIPF0000091; mir-368

Literature search

52 open access papers mention hsa-mir-376b
(92 sentences)

Stem-loop

       ccuuc         u           a     u     uuuacg    u 
5' cagu     uuugguauu aaaacguggau uuccu cuaug      ugau c
   ||||     ||||||||| ||||||||||| ||||| |||||      |||| c
3' gucg     aaacuauga uuuuguaccua aagga gauac      auug u
       ----u         c           a     -     ----ua    g 

Deep sequencing

17194 reads, 116 reads per million, 132 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

The mature miR-376b products have been shown to be modified by A to I edits [2].

Genome context

• Coordinates (GRCh38; GCA_000001405.15): chr14: 101040436-101040535 [+]
• Overlapping transcripts:

  antisense

  OTTHUMT00000414335 ; BEGAIN-006; intron 1

  ENST00000554140 ; BEGAIN-006; intron 1

Clustered miRNAs

< 10kb from hsa-mir-376b

• hsa-mir-543: chr14: 101031987-101032064 [+]
• hsa-mir-495: chr14: 101033755-101033836 [+]
• hsa-mir-376c: chr14: 101039690-101039755 [+]
• hsa-mir-376a-2: chr14: 101040069-101040148 [+]
• hsa-mir-654: chr14: 101040219-101040299 [+]
• hsa-mir-376b: chr14: 101040436-101040535 [+]
• hsa-mir-376a-1: chr14: 101040782-101040849 [+]
• hsa-mir-300: chr14: 101041363-101041445 [+]
• hsa-mir-1185-1: chr14: 101042977-101043062 [+]
• hsa-mir-1185-2: chr14: 101044198-101044283 [+]
• hsa-mir-381: chr14: 101045920-101045994 [+]
• hsa-mir-487b: chr14: 101046455-101046538 [+]
• hsa-mir-539: chr14: 101047321-101047398 [+]
• hsa-mir-889: chr14: 101047901-101047979 [+]
• hsa-mir-544a: chr14: 101048658-101048748 [+]
• hsa-mir-655: chr14: 101049550-101049646 [+]

Database links

• EntrezGene:MIR376B
• HGNC:MIR376B
• RNAcentral:URS000075A7C0_9606
• miRBase Tracker:MI0002466

Mature sequence hsa-miR-376b-5p

• Accession: MIMAT0022923
• Sequence: 24 - cguggauauuccuucuauguuu - 45
• Deep sequencing: 862 reads, 105 experiments
• Evidence: experimental; SOLiD [4]
• Database links:
  • RNAcentral:URS000047736C_9606
• Predicted targets:
  • TargetScanVert:hsa-miR-376b-5p
  • miRDB:hsa-miR-376b-5p

Mature sequence hsa-miR-376b-3p

• Accession: MIMAT0002172
• Previous IDs: hsa-miR-376b
• Sequence: 62 - aucauagaggaaaauccauguu - 83
• Deep sequencing: 16245 reads, 132 experiments
• Evidence: experimental; cloned [3], SOLiD [4]
• Database links:
  • RNAcentral:URS00003AD231_9606
• Predicted targets:
  • TargetScanVert:hsa-miR-376b-3p
  • miRDB:hsa-miR-376b-3p
  • microrna.org:hsa-miR-376b-3p

References

1. PMID:15891114 "Clustering and conservation patterns of human microRNAs" Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H Nucleic Acids Res. 33:2697-2706(2005).
2. PMID:17322061 "Redirection of silencing targets by adenosine-to-inosine editing of miRNAs" Kawahara Y, Zinshteyn B, Sethupathy P, Iizasa H, Hatzigeorgiou AG, Nishikura K Science. 315:1137-1140(2007).
3. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
4. PMID:22282338 "Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs" Voellenkle C, Rooij Jv, Guffanti A, Brini E, Fasanaro P, Isaia E, Croft L, David M, Capogrossi MC, Moles A, Felsani A, Martelli F RNA. 18:472-484(2012).