miRBase entry: hcmv-mir-US5-1

Stem-loop hcmv-mir-US5-1


Accession
MI0001682
Description
Human cytomegalovirus hcmv-mir-US5-1 precursor miRNA


Sequence

ugaacgcuuucgucguguuuuucaugcagcuuuuacagaccaUGACAAGCCUGACGAGAGCGUuca
(((((((((((((((.((((.(((((...((.....))..))))).)))).)))))))))))))))

Structure
               u    u     cag  u 
ugaacgcuuucgucg guuu ucaug   cu u
||||||||||||||| |||| |||||   || u
acuUGCGAGAGCAGU CGAA AGUac   ga a
               C    C     -ca  c 


Annotation confidence Not enough data
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Genome context
HEHCMVCG: 196060-196125 [+]
Clustered miRNAs
2 other miRNAs are < 10 kb from hcmv-mir-US5-1
Name Accession Chromosome Start End Strand Confidence




Disease association
hcmv-mir-US5-1 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hcmv-miR-US5-1

Accession MIMAT0001579
Description Human cytomegalovirus hcmv-miR-US5-1 mature miRNA
Sequence 43 - UGACAAGCCUGACGAGAGCGU - 63
Evidence experimental
cloned [1,3], Northern [2], Illumina [4-5]

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 15782219
    Identification of microRNAs of the herpesvirus family
    "Pfeffer S, Sewer A, Lagos-Quintana M, Sheridan R, Sander C, Grasser FA, van Dyk LF, Ho CK, Shuman S, Chien M, Russo JJ, Ju J, Randall G, Lindenbach BD, Rice CM, Simon V, Ho DD, Zavolan M, Tuschl T"
    "Nat Methods (2005) 2:269-276

  3. PubMed ID: 16140786
    Identification and characterization of human cytomegalovirus-encoded microRNAs
    "Grey F, Antoniewicz A, Allen E, Saugstad J, McShea A, Carrington JC, Nelson J"
    "J Virol (2005) 79:12095-12099

  4. PubMed ID: 22013051
    High-resolution profiling and analysis of viral and host small RNAs during human cytomegalovirus infection
    "Stark TJ, Arnold JD, Spector DH, Yeo GW"
    "J Virol (2012) 86:226-235

  5. PubMed ID: 22715351
    The microRNA Transcriptome of Human Cytomegalovirus (HCMV)
    "Meshesha MK, Veksler-Lublinsky I, Isakov O, Reichenstein I, Shomron N, Kedem K, Ziv-Ukelson M, Bentwich Z, Avni YS"
    "Open Virol J (2012) 6:38-48