Stem-loop sequence mmu-mir-434

Accession

MI0001526 (change log)

Symbol

MGI:Mir434

Description

Mus musculus miR-434 stem-loop

Gene family

MIPF0000439; mir-434

Literature search

19 open access papers mention mmu-mir-434
(111 sentences)

Stem-loop

   ucgacucug           -a  c    c c      ug      uacu 
5'          gguuugaacca  ag ucga u augguu  aaccau    u
            |||||||||||  || |||| | ||||||  ||||||     
3'          ccaagcuuggu  uc agcu a uaccaa  uuggug    a
   ------cua           cc  -    c c      gu      cuua 

Deep sequencing

914826 reads, 1.5e+03 reads per million, 93 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3]. The 5' end of the miRNA may be offset with respect to previous annotations.

Genome context

• Coordinates (GRCm38; GCA_000001635.2): chr12: 109594506-109594599 [+]
• Overlapping transcripts:

  antisense

  ENSMUST00000149046 ; Rtl1-201; exon 2

Clustered miRNAs

< 10kb from mmu-mir-434

• mmu-mir-337: chr12: 109585789-109585885 [+]
• mmu-mir-3544: chr12: 109585813-109585873 [-]
• mmu-mir-540: chr12: 109586080-109586146 [+]
• mmu-mir-665: chr12: 109586314-109586407 [+]
• mmu-mir-3070-1: chr12: 109587943-109588031 [+]
• mmu-mir-3070-2: chr12: 109588592-109588680 [+]
• mmu-mir-431: chr12: 109590447-109590537 [+]
• mmu-mir-433: chr12: 109591715-109591838 [+]
• mmu-mir-127: chr12: 109592846-109592915 [+]
• mmu-mir-434: chr12: 109594506-109594599 [+]
• mmu-mir-432: chr12: 109594956-109595030 [+]
• mmu-mir-3071: chr12: 109595318-109595397 [-]
• mmu-mir-136: chr12: 109595327-109595388 [+]

Database links

• EntrezGene:Mir434
• MGI:Mir434
• RNAcentral:URS00006596A5_10090
• miRBase Tracker:MI0001526

Mature sequence mmu-miR-434-5p

• Accession: MIMAT0001421
• Sequence: 23 - gcucgacucaugguuugaacca - 44
• Deep sequencing: 218782 reads, 78 experiments
• Evidence: experimental; PCR [1], cloned [2-3], Illumina [4-5]
• Database links:
  • RNAcentral:URS00001539CF_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-434-5p
  • miRDB:mmu-miR-434-5p
  • microrna.org:mmu-miR-434-5p

Mature sequence mmu-miR-434-3p

• Accession: MIMAT0001422
• Sequence: 60 - uuugaaccaucacucgacuccu - 81
• Deep sequencing: 695491 reads, 92 experiments
• Evidence: experimental; PCR [1], cloned [2-3], Illumina [4-5]
• Database links:
  • RNAcentral:URS000019C8F1_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-434-3p
  • miRDB:mmu-miR-434-3p
  • microrna.org:mmu-miR-434-3p

References

1. PMID:15854907 "RNAi-mediated allelic trans-interaction at the imprinted Rtl1/Peg11 locus" Davis E, Caiment F, Tordoir X, Cavaille J, Ferguson-Smith A, Cockett N, Georges M, Charlier C Curr Biol. 15:743-749(2005).
2. PMID:16274478 "Identification of clustered microRNAs using an ab initio prediction method" Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M BMC Bioinformatics. 6:267(2005).
3. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
4. PMID:20215419 "MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing" Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A Mol Hum Reprod. 16:463-471(2010).
5. PMID:20413612 "Mammalian microRNAs: experimental evaluation of novel and previously annotated genes" Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP Genes Dev. 24:992-1009(2010).