Accession
MI0001445
Symbol
HGNC:
MIR423
Description
Homo sapiens
hsa-mir-423 precursor miRNA
Gene family
MIPF0000329;
mir-423
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR423 is one of the 16 candidate miRNAs that have been studied for their potential involvement in diabetes [PMC7463887]. It is a type of miRNA that has been found to be altered in the plasma/serum of diabetic patients [PMC7463887]. In a study involving 47 T2D patients and 22 healthy subjects, the expression of MIR423, along with other miRNAs such as mir29a, mir34b, Xpo5, and several others, was found to be significantly different in leukoplakia tissues compared to control tissues [PMC4035900]. However, the expression of these genes was not modulated by genotypes at SNPs [PMC4035900]. This study aimed to investigate the potential involvement of these candidate miRNAs in diabetic retinopathy [PMC7463887]. The researchers analyzed plasma/serum samples from T2D patients with and without retinopathy as well as healthy subjects [PMC7463887'>PMC7463887]. The findings suggest that MIR423 and other miRNAs may play a role in the development or progression of diabetic retinopathy [PMC7463887]. Further research is needed to fully understand the mechanisms by which these miRNAs contribute to the pathogenesis of diabetes and its complications [PMC7463887].
Literature search
111 open access papers mention hsa-mir-423
(452 sentences)
(452 sentences)
Sequence
1378783
reads,
5810
reads per million, 159 experiments
auaaaggaaguuaggcUGAGGGGCAGAGAGCGAGACUUUucuauuuuccaaaAGCUCGGUCUGAGGCCCCUCAGUcuugcuuccuaacccgcgc
....(((((((.((((((((((((..(((.((((.(((((.........))))))))).)))...)))))))))))).))))))).........
....(((((((.((((((((((((..(((.((((.(((((.........))))))))).)))...)))))))))))).))))))).........
Structure
-----auaa u -AG G A cua
aggaagu aggcUGAGGGGC AGA CGAG CUUUu u
||||||| |||||||||||| ||| |||| ||||| u
uccuucg ucUGACUCCCCG UCU GCUC GAaaa u
cgcgcccaa u GAG G - ccu
Annotation confidence
High
Do you think this miRNA is real?
Comments
miR-423 (renamed miR-423-3p here) is expressed in human promyelocytic leukemia (HL-60) cells [1]. The level of expression was shown to be up-regulated 48 hours after TPA-induction. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].
Genome context
chr17: 30117079-30117172 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-423
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-423 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-423-5p
| Accession | MIMAT0004748 |
| Description | Homo sapiens hsa-miR-423-5p mature miRNA |
| Sequence | 17 - UGAGGGGCAGAGAGCGAGACUUU - 39 |
| Evidence |
experimental
cloned [2-4], Northern [4], Illumina [5] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-423-3p
| Accession | MIMAT0001340 |
| Description | Homo sapiens hsa-miR-423-3p mature miRNA |
| Sequence | 53 - AGCUCGGUCUGAGGCCCCUCAGU - 75 |
| Evidence |
experimental
cloned [1-2], Northern [1] |
| Database links |
|
| Predicted targets |
|
References
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