miRBase entry: gga-mir-33-1

Stem-loop gga-mir-33-1


Accession
MI0001170
Description
Gallus gallus gga-mir-33-1 precursor miRNA
Gene family
MIPF0000070; mir-33

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

Gga-mir-33 is a microRNA found in chickens that plays a role in regulating fatty acid oxidation in the liver [PMC7936154]. It is homologous to gga-mir-33* [PMC3005926]. Studies have shown that gga-mir-33 targets enzymes involved in fatty acid oxidation, such as CROT, HADHB, and FTO [PMC7936154]. In the liver of newly hatched chicks subjected to a delay in feeding, the expression of gga-mir-33 is significantly lower compared to chicks that were fed from hatch [PMC7936154]. This suggests that gga-mir-33 may negatively regulate fatty acid oxidation when chicks rely on residual yolk lipids for energy production [PMC7936154'>PMC7936154].

The expression of gga-mir-33 increases from hatching through the first weeks of posthatch life [PMC7936154]. It has been predicted that gga-mir-33 targets various enzymes involved in metabolic signaling cascades and effector enzymes related to lipid metabolism [PMC7936154].

Gga-mir-33 has been found to regulate fat mass and obesity-associated (FTO) genes associated with obesity in chicken liver, similar to its function in mammals such as humans and mice [PMC7084605]. Studies have shown that gga-mir-33 is closely related to lipid metabolism and fatty acid oxidation by regulating FTO, CROT, and HADHB genes in chicken liver [PMC9714206].

Furthermore, gga-mir-33 and its host gene SREBF2 are highly expressed in the chicken liver, suggesting their involvement in upregulating genes related to cholesterol biosynthesis [PMC3675212].

Literature search
8 open access papers mention gga-mir-33-1
(121 sentences)

Sequence

24272 reads, 294 reads per million, 5 experiments
cuguaGUGCAUUGUAGUUGCAUUGCaugugcuggcaguaacugugcAAUGUUCCUGCAGUGCAGUAcag
(((((.((((((((((..(((((((((.((((...))))...)))))))))..)))))))))).)))))

Structure
     G          UU         --g    g 
cugua UGCAUUGUAG  GCAUUGCau   ugcu  
||||| ||||||||||  |||||||||   |||| g
gacAU ACGUGACGUC  UGUAAcgug   auga  
     G          CU         uca    c 


Annotation confidence High
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Genome context
chr1: 49529873-49529941 [-]

Database links

Mature gga-miR-33-5p

Accession MIMAT0001100
Description Gallus gallus gga-miR-33-5p mature miRNA
Sequence 6 - GUGCAUUGUAGUUGCAUUGC - 25
Evidence experimental
cloned [1-2], Illumina [3]
Database links
Predicted targets

Mature gga-miR-33-3p

Accession MIMAT0026490
Description Gallus gallus gga-miR-33-3p mature miRNA
Sequence 47 - AAUGUUCCUGCAGUGCAGUA - 66
Evidence experimental
Illumina [3]
Database links
Predicted targets

References

  1. PubMed ID: 18256158
    MicroRNA profile of Marek's disease virus-transformed T-cell line MSB-1: predominance of virus-encoded microRNAs
    "Yao Y, Zhao Y, Xu H, Smith LP, Lawrie CH, Watson M, Nair V"
    "J Virol (2008) 82:4007-4015

  2. PubMed ID: 18463306
    Conservation of small RNA pathways in platypus
    "Murchison EP, Kheradpour P, Sachidanandam R, Smith C, Hodges E, Xuan Z, Kellis M, Grutzner F, Stark A, Hannon GJ"
    "Genome Res (2008) 18:995-1004

  3. PubMed ID: 23034410
    Birth and expression evolution of mammalian microRNA genes
    "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
    "Genome Res (2013) 23:34-45