Stem-loop sequence hsa-mir-337

Accession

MI0000806 (change log)

Symbol

HGNC:MIR337

Description

Homo sapiens miR-337 stem-loop

Gene family

MIPF0000195; mir-337

Literature search

53 open access papers mention hsa-mir-337
(192 sentences)

Stem-loop

   guagucagua uu         -   c   u     c        -   ca 
5'           g  ggggggugg gaa ggc ucaua aggaguug aug  c
             |  ||||||||| ||| ||| ||||| |||||||| |||   
3'           c  uccccuacu cuu ccg aguau uccucgac uau  a
   --------aa -u         u   u   u     a        c   ug 

Deep sequencing

14094 reads, 21.7 reads per million, 120 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

This sequence was predicted based on homology with a verified rat miRNA [1,2], and later confirmed in human [3].

Genome context

• Coordinates (GRCh38; GCA_000001405.15): chr14: 100874493-100874585 [+]
• Overlapping transcripts:

  sense

  OTTHUMT00000414309 ; WDR25-007; intron 1

  OTTHUMT00000414313 ; WDR25-008; intron 1

  OTTHUMT00000414315 ; WDR25-005; intron 1

  OTTHUMT00000414316 ; WDR25-006; intron 1

  OTTHUMT00000414310 ; WDR25-002; intron 2

  OTTHUMT00000414311 ; WDR25-001; intron 2

  OTTHUMT00000414312 ; WDR25-004; intron 2

  OTTHUMT00000414314 ; WDR25-003; intron 2

  ENST00000555775 ; WDR25-007; intron 1

  ENST00000554492 ; WDR25-008; intron 1

  ENST00000557710 ; WDR25-005; intron 1

  ENST00000542471 ; WDR25-006; intron 1

  ENST00000554998 ; WDR25-002; intron 2

  ENST00000402312 ; WDR25-001; intron 2

  ENST00000335290 ; WDR25-004; intron 2

  ENST00000554175 ; WDR25-003; intron 2

Clustered miRNAs

< 10kb from hsa-mir-337

• hsa-mir-493: chr14: 100869060-100869148 [+]
• hsa-mir-337: chr14: 100874493-100874585 [+]
• hsa-mir-665: chr14: 100875033-100875104 [+]
• hsa-mir-431: chr14: 100881007-100881120 [+]
• hsa-mir-433: chr14: 100881886-100881978 [+]
• hsa-mir-127: chr14: 100882979-100883075 [+]
• hsa-mir-432: chr14: 100884483-100884576 [+]

Database links

• EntrezGene:MIR337
• HGNC:MIR337
• RNAcentral:URS000075CFEA_9606
• miRBase Tracker:MI0000806

Mature sequence hsa-miR-337-5p

• Accession: MIMAT0004695
• Sequence: 23 - gaacggcuucauacaggaguu - 43
• Deep sequencing: 6804 reads, 109 experiments
• Evidence: experimental; cloned [3]
• Database links:
  • RNAcentral:URS0000306C70_9606
• Predicted targets:
  • TargetMiner:hsa-miR-337-5p
  • TargetScanVert:hsa-miR-337-5p
  • miRDB:hsa-miR-337-5p
  • microrna.org:hsa-miR-337-5p

Mature sequence hsa-miR-337-3p

• Accession: MIMAT0000754
• Previous IDs: hsa-miR-337
• Sequence: 61 - cuccuauaugaugccuuucuuc - 82
• Deep sequencing: 7269 reads, 119 experiments
• Evidence: experimental; cloned [3]
• Database links:
  • RNAcentral:URS0000564D66_9606
• Predicted targets:
  • TargetMiner:hsa-miR-337-3p
  • TargetScanVert:hsa-miR-337-3p
  • miRDB:hsa-miR-337-3p
  • microrna.org:hsa-miR-337-3p

References

1. PMID:14691248 "Identification of many microRNAs that copurify with polyribosomes in mammalian neurons" Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G Proc Natl Acad Sci U S A. 101:360-365(2004).
2. PMID:15634332 "New human and mouse microRNA genes found by homology search" Weber MJ FEBS J. 272:59-73(2005).
3. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).