miRBase entry: hsa-mir-377

Stem-loop hsa-mir-377


Accession
MI0000785
Symbol
HGNC: MIR377
Description
Homo sapiens hsa-mir-377 precursor miRNA
Gene family
MIPF0000018; mir-154

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR377 is a microRNA that is overexpressed in GH-, TSH-, and PRL-secreting adenomas [PMC7652879]. It has been shown to influence myocardial regeneration and angiogenesis by targeting genes involved in inflammation, oxidative stress, and angiogenesis [PMC7527411]. Additionally, MIR377 has been found to regulate metastatic capability by inhibiting the process of epithelial-mesenchymal transition (EMT) and inactivating the Wnt/β-catenin pathway [PMC9212183]. It has also been implicated in gastric cancer cell proliferation [PMC5795907]. MIR377 interacts with various genes, including NEAT1, pseudogenes (RPL7P27, RPL7P27, RP11-618N24, SPCS2P1, RP11-209D20, RPL27AP5, MTND2P28, RP11-618N24, NSUN5P1, FTLP10), miRNAs (MIR204,MIR449A,MIR506,MIR335,MIR181D,MIR107), protein-coding genes,rRNAs ,snRNAs ,and tRNA [PMC9730017]. Furthermore,it is upregulated after IFN-γ stimulation [PMC8010072]. MIR377 has also been studied in the context of glioma-conditioned endothelial cells (GECs) and its possible regulatory relationships with piR-DQ590027,MIR17HG ,miR-153,and FOXR2 on the permeability of glioma-conditioned normal blood-brain barrier (BBB) [PMC6180493]. Additionally,luteolin treatment downregulated MIR377 expression in glioma cells[PMC4791268]. Overall,Mir377 plays a role in various biological processes including adenoma development and metastasis regulation.

Literature search
65 open access papers mention hsa-mir-377
(519 sentences)

Sequence

2013 reads, 94 reads per million, 87 experiments
uugagcAGAGGUUGCCCUUGGUGAAUUCgcuuuauuuauguugaAUCACACAAAGGCAACUUUUGUuug
..((((((((((((((.(((((((.(((((.........).)))))))).))).)))))))))))))).

Structure
uu              C   -    A    - uuu 
  gagcAGAGGUUGCC UUG GUGA UUCg c   a
  |||||||||||||| ||| |||| |||| |   u
  uuUGUUUUCAACGG AAC CACU Aagu g   u
-g              A   A    -    u uau 


Annotation confidence High
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Genome context
chr14: 101062050-101062118 [+]
Clustered miRNAs
14 other miRNAs are < 10 kb from hsa-mir-377
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-377 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-377-5p

Accession MIMAT0004689
Description Homo sapiens hsa-miR-377-5p mature miRNA
Sequence 7 - AGAGGUUGCCCUUGGUGAAUUC - 28
Evidence experimental
cloned [3]
Database links
Predicted targets

Mature hsa-miR-377-3p

Accession MIMAT0000730
Description Homo sapiens hsa-miR-377-3p mature miRNA
Sequence 45 - AUCACACAAAGGCAACUUUUGU - 66
Evidence experimental
cloned [1-3]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 15891114
    Clustering and conservation patterns of human microRNAs
    "Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H"
    "Nucleic Acids Res (2005) 33:2697-2706

  3. PubMed ID: 16274478
    Identification of clustered microRNAs using an ab initio prediction method
    Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
    BMC Bioinformatics (2005) 6:267