miRBase entry: hsa-mir-375

Stem-loop hsa-mir-375


Accession
MI0000783
Symbol
HGNC: MIR375
Description
Homo sapiens hsa-mir-375 precursor miRNA
Gene family
MIPF0000114; mir-375

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR375 is a microRNA that is specifically expressed in islet cells and is believed to play a role in the early stages of islet development [PMC4700298]. It is particularly involved in the differentiation of embryonic stem cells into liver and insulin secretory cells [PMC4700298]. In the context of post-chemotherapy residual disease, an integrated analysis of miR371 and MIR375 has been proposed to predict the risk of aGCM (acute graft-versus-host disease) and teratoma in patients [PMC8575592]. In certain cases, MIR375, along with WWOX (WW domain containing oxidoreductase), can inhibit autophagy and promote chemosensitivity of cancer cells [PMC8939209]. It has been suggested that PB1 may enhance the function of DC (dendritic cells) by down-regulating MIR375 [PMC5360757]. Furthermore, line chart results have shown that miR-1, miR122, MIR375, and miR-328 exhibit changes in concentration earlier than cardiac troponin I. Additionally, some miRNAs demonstrate more pronounced changes than others [PMC3922900]. Overall, MIR375 has been implicated in various biological processes such as islet development, cancer chemosensitivity modulation, and immune cell function.

Literature search
256 open access papers mention hsa-mir-375
(1718 sentences)

Sequence

258390 reads, 1004 reads per million, 138 experiments
ccccGCGACGAGCCCCUCGCACAAACCggaccugagcguUUUGUUCGUUCGGCUCGCGUGAggc
.((((((.((((((...((.(((((.((........)).))))).))...)))))))))).)).

Structure
c  -    A      CCU  C     C  gac 
 cc cGCG CGAGCC   CG ACAAA Cg   c
 || |||| ||||||   || ||||| ||    
 gg GUGC GCUCGG   GC UGUUU gc   u
c  A    -      CUU  U     u  gag 


Annotation confidence High
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Genome context
chr2: 219001645-219001708 [-]

Disease association
hsa-mir-375 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-375-3p

Accession MIMAT0000728
Description Homo sapiens hsa-miR-375-3p mature miRNA
Sequence 40 - UUUGUUCGUUCGGCUCGCGUGA - 61
Evidence experimental
cloned [2]
Database links
Predicted targets

Mature hsa-miR-375-5p

Accession MIMAT0037313
Description Homo sapiens hsa-miR-375-5p mature miRNA
Sequence 5 - GCGACGAGCCCCUCGCACAAACC - 27
Evidence not_experimental

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 15538371
    A pancreatic islet-specific microRNA regulates insulin secretion
    "Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M"
    "Nature (2004) 432:226-230