Stem-loop sequence mmu-mir-92a-1

Accession

MI0000719 (change log)

Previous IDs

mmu-mir-92-1

Description

Mus musculus miR-92a-1 stem-loop

Gene family

MIPF0000013; mir-25

Literature search

139 open access papers mention mmu-mir-92a-1
(864 sentences)

Stem-loop

   ---cu   uac            uu  c           uuu 
5'      uuc   acagguugggau  gu gcaaugcugug   c
        |||   ||||||||||||  || |||||||||||    
3'      gag   uguccggcccug  ca cguuaugguau   u
   gguuu   --u            uu  -           guc 

Deep sequencing

5766510 reads, 1.23e+04 reads per million, 107 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

The predominant miR-92 form cloned by Landgraf et al. has a additional 3' U residue, which is compatible with this precursor sequence, but not with that of mir-92-2 (MI0000580) [4].

Genome context

• Coordinates (GRCm38; GCA_000001635.2): chr14: 115044427-115044506 [+]
• Overlapping transcripts:

  sense

  OTTMUST00000083388 ; Mir17hg-001; exon 2

  ENSMUST00000134140 ; Mir17hg-001; exon 2

Clustered miRNAs

< 10kb from mmu-mir-92a-1

• mmu-mir-17: chr14: 115043671-115043754 [+]
• mmu-mir-18a: chr14: 115043851-115043946 [+]
• mmu-mir-19a: chr14: 115044000-115044081 [+]
• mmu-mir-20a: chr14: 115044157-115044263 [+]
• mmu-mir-19b-1: chr14: 115044305-115044391 [+]
• mmu-mir-92a-1: chr14: 115044427-115044506 [+]

Database links

• EntrezGene:Mirn92-1
• RNAcentral:URS00006CA851_10090
• miRBase Tracker:MI0000719

Mature sequence mmu-miR-92a-1-5p

• Accession: MIMAT0017066
• Previous IDs: mmu-miR-92a-1*
• Sequence: 11 - agguugggauuugucgcaaugcu - 33
• Deep sequencing: 23341 reads, 98 experiments
• Evidence: experimental; 454 [6], Illumina [7]
• Database links:
  • RNAcentral:URS00004C89D9_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-92a-1-5p
  • miRDB:mmu-miR-92a-1-5p

Mature sequence mmu-miR-92a-3p

• Accession: MIMAT0000539
• Previous IDs: mmu-miR-92;mmu-miR-92a
• Sequence: 50 - uauugcacuugucccggccug - 70
• Deep sequencing: 10803467 reads, 107 experiments
• Evidence: experimental; cloned [1,3-4], Northern [1], Illumina [5,7]
• Database links:
  • RNAcentral:URS0000329B12_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-92a-3p
  • miRDB:mmu-miR-92a-3p
  • microrna.org:mmu-miR-92a-3p

References

1. PMID:12919684 "Embryonic stem cell-specific MicroRNAs" Houbaviy HB, Murray MF, Sharp PA Dev Cell. 5:351-358(2003).
2. PMID:15634332 "New human and mouse microRNA genes found by homology search" Weber MJ FEBS J. 272:59-73(2005).
3. PMID:16766679 "Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes" Watanabe T, Takeda A, Tsukiyama T, Mise K, Okuno T, Sasaki H, Minami N, Imai H Genes Dev. 20:1732-1743(2006).
4. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
5. PMID:20215419 "MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing" Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A Mol Hum Reprod. 16:463-471(2010).
6. PMID:20668074 "Identification and analysis of expression of novel microRNAs of murine gammaherpesvirus 68" Zhu JY, Strehle M, Frohn A, Kremmer E, Hofig KP, Meister G, Adler H J Virol. 84:10266-10275(2010).
7. PMID:20413612 "Mammalian microRNAs: experimental evaluation of novel and previously annotated genes" Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP Genes Dev. 24:992-1009(2010).