Stem-loop sequence mmu-mir-19b-2

Accession

MI0000546 (change log)

Previous IDs

mmu-mir-19b

Symbol

MGI:Mir19b-2

Description

Mus musculus miR-19b-2 stem-loop

Gene family

MIPF0000011; mir-19

Literature search

124 open access papers mention mmu-mir-19b-2
(748 sentences)

Stem-loop

   a                  --        guu    -      g 
5'  cuuacgauuaguuuugca  gauuugca   cagc guauau u
    ||||||||||||||||||  ||||||||   |||| ||||||  
3'  ggguguuagucaaaacgu  cuaaacgu   gucg uauaua g
   a                  ac        ---    g      a 

Deep sequencing

369758 reads, 2.82e+03 reads per million, 107 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

Mouse miR-19b was cloned from mouse tissues by independent groups [1,2]. There are two predicted hairpin precursors, with closely related human homologues [4]: mir-19b-1 (MI0000718) on chromosome 14, and mir-19b-2 (previously named mir-19b here, MI0000546) on mouse chromosome X.

Genome context

• Coordinates (GRCm38; GCA_000001635.2): chrX: 52741983-52742066 [-]
• Overlapping transcripts:

  intergenic

Clustered miRNAs

< 10kb from mmu-mir-19b-2

• mmu-mir-106a: chrX: 52742503-52742567 [-]
• mmu-mir-18b: chrX: 52742331-52742413 [-]
• mmu-mir-20b: chrX: 52742113-52742192 [-]
• mmu-mir-19b-2: chrX: 52741983-52742066 [-]
• mmu-mir-92a-2: chrX: 52741838-52741928 [-]
• mmu-mir-363: chrX: 52741693-52741767 [-]

Database links

• EntrezGene:Mirn19b-2
• MGI:Mir19b-2
• RNAcentral:URS000075C542_10090
• miRBase Tracker:MI0000546

Mature sequence mmu-miR-19b-2-5p

• Accession: MIMAT0017010
• Previous IDs: mmu-miR-19b-2*
• Sequence: 11 - aguuuugcagauuugcaguucagc - 34
• Deep sequencing: 29 reads, 14 experiments
• Evidence: experimental; Illumina [7]
• Predicted targets:
  • TargetScanVert:mmu-miR-19b-2-5p
  • miRDB:mmu-miR-19b-2-5p

Mature sequence mmu-miR-19b-3p

• Accession: MIMAT0000513
• Previous IDs: mmu-miR-19b
• Sequence: 54 - ugugcaaauccaugcaaaacuga - 76
• Deep sequencing: 736255 reads, 107 experiments
• Evidence: experimental; cloned [1-3,5], Northern [2], Illumina [6,8]
• Database links:
  • RNAcentral:URS000013D17D_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-19b-3p
  • miRDB:mmu-miR-19b-3p
  • microrna.org:mmu-miR-19b-3p

References

1. PMID:12007417 "Identification of tissue-specific microRNAs from mouse" Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T Curr Biol. 12:735-739(2002).
2. PMID:12919684 "Embryonic stem cell-specific MicroRNAs" Houbaviy HB, Murray MF, Sharp PA Dev Cell. 5:351-358(2003).
3. PMID:12554860 "Numerous microRNPs in neuronal cells containing novel microRNAs" Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G RNA. 9:180-186(2003).
4. PMID:15634332 "New human and mouse microRNA genes found by homology search" Weber MJ FEBS J. 272:59-73(2005).
5. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
6. PMID:20215419 "MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing" Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A Mol Hum Reprod. 16:463-471(2010).
7. PMID:20413612 "Mammalian microRNAs: experimental evaluation of novel and previously annotated genes" Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP Genes Dev. 24:992-1009(2010).