Stem-loop sequence hsa-mir-146a

Accession

MI0000477 (change log)

Previous IDs

hsa-mir-146

Symbol

HGNC:MIR146A

Description

Homo sapiens miR-146a stem-loop

Gene family

MIPF0000103; mir-146

Literature search

749 open access papers mention hsa-mir-146a
(6672 sentences)

Stem-loop

   c     -----u      u     uu            c  u     g  uc 
5'  cgaug      guaucc cagcu  gagaacugaauu ca ggguu ug  a
    |||||      |||||| |||||  |||||||||||| || ||||| ||  g
3'  gcuac      uauagg gucga  uucuugacuuaa gu uccag ac  u
   u     ugucuc      -     -c            a  c     -  ug 

Deep sequencing

1355616 reads, 2.37e+03 reads per million, 160 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1]. Its expression was later verified in human [2,3].

Genome context

• Coordinates (GRCh38; GCA_000001405.15): chr5: 160485352-160485450 [+]
• Overlapping transcripts:

  intergenic

Database links

• EntrezGene:MIR146A
• HGNC:MIR146A
• RNAcentral:URS000075D8A0_9606
• miRBase Tracker:MI0000477

Mature sequence hsa-miR-146a-5p

• Accession: MIMAT0000449
• Previous IDs: hsa-miR-146;hsa-miR-146a
• Sequence: 21 - ugagaacugaauuccauggguu - 42
• Deep sequencing: 1354966 reads, 160 experiments
• Evidence: experimental; cloned [2-3]
• Database links:
  • RNAcentral:URS000050B527_9606
• Predicted targets:
  • TargetMiner:hsa-miR-146a-5p
  • TargetScanVert:hsa-miR-146a-5p
  • miRDB:hsa-miR-146a-5p
  • microrna.org:hsa-miR-146a-5p

Mature sequence hsa-miR-146a-3p

• Accession: MIMAT0004608
• Previous IDs: hsa-miR-146a*
• Sequence: 57 - ccucugaaauucaguucuucag - 78
• Deep sequencing: 599 reads, 79 experiments
• Evidence: experimental; cloned [3]
• Database links:
  • RNAcentral:URS00001EFBE3_9606
• Predicted targets:
  • TargetMiner:hsa-miR-146a-3p
  • TargetScanVert:hsa-miR-146a-3p
  • miRDB:hsa-miR-146a-3p
  • microrna.org:hsa-miR-146a-3p

References

1. PMID:12007417 "Identification of tissue-specific microRNAs from mouse" Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T Curr Biol. 12:735-739(2002).
2. PMID:15800047 "Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells" Cai X, Lu S, Zhang Z, Gonzalez CM, Damania B, Cullen BR Proc Natl Acad Sci U S A. 102:5570-5575(2005).
3. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).