Stem-loop hsa-mir-153-2

Accession

MI0000464

Symbol

HGNC: MIR153-2

Description

Homo sapiens hsa-mir-153-2 precursor miRNA

Gene family

MIPF0000050; mir-153

Literature search

69 open access papers mention hsa-mir-153-2
(684 sentences)

Sequence

22043 reads, 451 reads per million, 98 experiments

agcgguggccagugUCAUUUUUGUGAUGUUGCAGCUaguaauaugagcccagUUGCAUAGUCACAAAAGUGAUCauuggaaacugug
.(((((..(((((((((((((((((((..(((((((.((.......))..)))))))..))))))))))))).))))))..))))).

Structure

a     gg      -             GU       -a  aa 
 gcggu  ccagug UCAUUUUUGUGAU  UGCAGCU  gu  u
 |||||  |||||| |||||||||||||  |||||||  ||  a
 uguca  gguuaC AGUGAAAACACUG  ACGUUga  cg  u
g     aa      U             AU       cc  ag 

Annotation confidence High

Comments

This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1], later verified in human [2].

Genome context

chr7: 157574336-157574422 [-]

Disease association

hsa-mir-153-2 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-153-3p

• Accession: MIMAT0000439
• Description: Homo sapiens hsa-miR-153-3p mature miRNA
• Sequence: 53 - UUGCAUAGUCACAAAAGUGAUC - 74
• Evidence: experimental ; cloned [2], Illumina [3]

Mature hsa-miR-153-5p

• Accession: MIMAT0026480
• Description: Homo sapiens hsa-miR-153-5p mature miRNA
• Sequence: 15 - UCAUUUUUGUGAUGUUGCAGCU - 36
• Evidence: experimental ; Illumina [3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739


3. PubMed ID: 23034410
   Birth and expression evolution of mammalian microRNA genes
   "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
   "Genome Res (2013) 23:34-45