miRBase entry: hsa-mir-142

Stem-loop hsa-mir-142


Accession
MI0000458
Symbol
HGNC: MIR142
Description
Homo sapiens hsa-mir-142 precursor miRNA
Gene family
MIPF0000084; mir-142

Literature search
284 open access papers mention hsa-mir-142
(1956 sentences)

Sequence

381614 reads, 4761 reads per million, 132 experiments
gacagugcagucaccCAUAAAGUAGAAAGCACUACUaacagcacuggagggUGUAGUGUUUCCUACUUUAUGGAugaguguacugug
.((((((((.(((.(((((((((((.(((((((((...(..(....)..)..))))))))).))))))))))).))).)))))))).

Structure
g        g   c           A         Uaa ag a 
 acagugca uca cCAUAAAGUAG AAGCACUAC   c  c c
 |||||||| ||| ||||||||||| |||||||||   |  |  
 ugucaugu agu GGUAUUUCAUC UUUGUGAUG   g  g u
g        g   A           C         -Ug ga g 


Annotation confidence High
Do you think this miRNA is real?
Comments
This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1]. Michael et al. verified the expression of a sequence from the 3' arm of this stem-loop (named miR-142-3p here) [2], and both miR-142-5p (from the 5' arm) and miR-142-3p ware later detected in human HL-60 leukemia cells [3]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].

Genome context
chr17: 58331232-58331318 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-142
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-142 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-142-5p

Accession MIMAT0000433
Description Homo sapiens hsa-miR-142-5p mature miRNA
Sequence 16 - CAUAAAGUAGAAAGCACUACU - 36
Evidence experimental
cloned [3-4]
Database links
Predicted targets

Mature hsa-miR-142-3p

Accession MIMAT0000434
Description Homo sapiens hsa-miR-142-3p mature miRNA
Sequence 52 - UGUAGUGUUUCCUACUUUAUGGA - 74
Evidence experimental
cloned [2-4]
Database links
Predicted targets

References

  1. PubMed ID: 14573789
    Reduced accumulation of specific microRNAs in colorectal neoplasia
    "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
    "Mol Cancer Res (2003) 1:882-891

  2. PubMed ID: 15325244
    Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
    "Kasashima K, Nakamura Y, Kozu T"
    "Biochem Biophys Res Commun (2004) 322:403-410

  3. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  4. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739