Stem-loop sequence hsa-mir-132

Accession

MI0000449 (change log)

Symbol

HGNC:MIR132

Description

Homo sapiens miR-132 stem-loop

Gene family

MIPF0000065; mir-132

Literature search

285 open access papers mention hsa-mir-132
(1553 sentences)

Stem-loop

   c   cccc    -  c a    a         uuc          --gu g 
5'  cgc    gcgu cu c gggc accguggcu   gauuguuacu    g g
    |||    |||| || | |||| |||||||||   ||||||||||    |  
3'  gcg    cgca ga g cccg ugguaccga   cugacaaugg    c a
   c   cacc    c  c c    c         cau          aggu a 

Deep sequencing

82337 reads, 752 reads per million, 157 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1], later verified in human [2].

Genome context

• Coordinates (GRCh38; GCA_000001405.15): chr17: 2049908-2050008 [-]
• Overlapping transcripts:

  sense

  OTTHUMT00000438476 ; SMG6-011; intron 1

  OTTHUMT00000438474 ; SMG6-010; intron 2

  OTTHUMT00000438059 ; SMG6-005; intron 5

  OTTHUMT00000438057 ; SMG6-002; intron 6

  OTTHUMT00000437826 ; SMG6-001; intron 13

  ENST00000570874 ; SMG6-011; intron 1

  ENST00000575454 ; SMG6-010; intron 2

  ENST00000536871 ; SMG6-005; intron 5

  ENST00000354901 ; SMG6-002; intron 6

  ENST00000263073 ; SMG6-001; intron 13

  ENST00000544865 ; SMG6-201; intron 13

Clustered miRNAs

< 10kb from hsa-mir-132

• hsa-mir-212: chr17: 2050271-2050380 [-]
• hsa-mir-132: chr17: 2049908-2050008 [-]

Database links

• EntrezGene:MIR132
• HGNC:MIR132
• RNAcentral:URS00001F4E81_9606
• miRBase Tracker:MI0000449

Mature sequence hsa-miR-132-5p

• Accession: MIMAT0004594
• Previous IDs: hsa-miR-132*
• Sequence: 23 - accguggcuuucgauuguuacu - 44
• Deep sequencing: 9417 reads, 153 experiments
• Evidence: experimental; cloned [2]
• Database links:
  • RNAcentral:URS0000028BB8_9606
• Predicted targets:
  • TargetMiner:hsa-miR-132-5p
  • TargetScanVert:hsa-miR-132-5p
  • miRDB:hsa-miR-132-5p
  • microrna.org:hsa-miR-132-5p

Mature sequence hsa-miR-132-3p

• Accession: MIMAT0000426
• Previous IDs: hsa-miR-132
• Sequence: 59 - uaacagucuacagccauggucg - 80
• Deep sequencing: 72776 reads, 156 experiments
• Evidence: experimental; cloned [2-3]
• Database links:
  • RNAcentral:URS00006054DA_9606
• Predicted targets:
  • TargetMiner:hsa-miR-132-3p
  • TargetScanVert:hsa-miR-132-3p
  • miRDB:hsa-miR-132-3p
  • microrna.org:hsa-miR-132-3p

References

1. PMID:12007417 "Identification of tissue-specific microRNAs from mouse" Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T Curr Biol. 12:735-739(2002).
2. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
3. PMID:17616659 "Patterns of known and novel small RNAs in human cervical cancer" Lui WO, Pourmand N, Patterson BK, Fire A Cancer Res. 67:6031-6043(2007).