Accession
MI0000431
Description
Drosophila melanogaster
dme-mir-2c precursor miRNA
Gene family
MIPF0000049;
mir-2
Literature search
28 open access papers mention dme-mir-2c
(104 sentences)
(104 sentences)
Sequence
81091
reads,
2932
reads per million, 49 experiments
ucguaucuuacuuucaaugUCAUCAAAAAGGGCUGAAGAAAGAUauuucugcauuugaaucgUAUCACAGCCAGCUUUGAUGGGCauugcaaugagcagcga
((((..((((.((.(((((((((((((...(((((......((((((((.......)))..))))).)))))...)))))).))))))).))))))..))))
((((..((((.((.(((((((((((((...(((((......((((((((.......)))..))))).)))))...)))))).))))))).))))))..))))
Structure
au c u - AAG AAGAAA -- ug
ucgu cuua uu caaugUC AUCAAA GGCUG GAUau uuc c
|||| |||| || ||||||| |||||| ||||| ||||| ||| a
agcg gagu aa guuaCGG UAGUUU CCGAC CUAUg aag u
ac - c G CGA -----A cu uu
Annotation confidence
High
Do you think this miRNA is real?
Comments
miR-2c was predicted by similarity to miR-2a (MIR:MI0000117). Expression in Drosophila was independently confirmed by Northern blot analysis [1] and by cloning [2]. The latter study confirmed the ends of the excised miR. Stark et al. [3] have identified targets for miR-2 in Drosophila using computational prediction followed by experimental validation. miR-2 regulates the proapoptotic genes reaper, grim and sickle, suggesting that it may be involved in the control of apoptosis.
Genome context
chr3R: 15417744-15417845 [-]
Clustered miRNAs
2 other miRNAs are < 10 kb from dme-mir-2c
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Database links
Mature dme-miR-2c-3p
| Accession | MIMAT0000411 |
| Description | Drosophila melanogaster dme-miR-2c-3p mature miRNA |
| Sequence | 63 - UAUCACAGCCAGCUUUGAUGGGC - 85 |
| Evidence |
experimental
Northern [1], cloned [2], 454 [4-5], Illumina [5] |
| Database links |
|
| Predicted targets |
|
Mature dme-miR-2c-5p
| Accession | MIMAT0020845 |
| Description | Drosophila melanogaster dme-miR-2c-5p mature miRNA |
| Sequence | 20 - UCAUCAAAAAGGGCUGAAGAAAGAU - 44 |
| Evidence | not_experimental |
| Database links |
|
References
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