miRBase entry: mmu-mir-199a-1

Stem-loop mmu-mir-199a-1


Accession
MI0000241
Symbol
MGI: Mir199a-1
Description
Mus musculus mmu-mir-199a-1 precursor miRNA
Gene family
MIPF0000040; mir-199

Literature search
163 open access papers mention mmu-mir-199a-1
(1314 sentences)

Sequence

3288633 reads, 18091 reads per million, 106 experiments
gccauCCCAGUGUUCAGACUACCUGUUCaggaggcugggacauguACAGUAGUCUGCACAUUGGUUAggc
(((...(((((((.((((((((.(((((((....)))).......))))))))))).)))))))...)))

Structure
   auC       U        C   -------    g 
gcc   CCAGUGU CAGACUAC UGU       UCag a
|||   ||||||| |||||||| |||       ||||  
cgg   GGUUACA GUCUGAUG ACA       gguc g
   AUU       C        -   uguacag    g 


Annotation confidence High
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Comments
The hairpin precursor sequence mir-199 maps to two loci within 50 kb on mouse chromosome 9. This sequence was named mir-199 in [1] and [2], but is renamed here to avoid overlap with the predicted homologues of human mir-199a-2 and mir-199b. Landgraf et al. demonstrate comparable expression for products from both arms of the hairpin, which are therefore renamed miR-199a-5p and miR-199a-3p here [4]. The mature sequences shown here represent the most commonly cloned forms from large-scale cloning studies [4]. The 5' end of the miRNA may be offset with respect to previous annotations.

Genome context
chr9: 21496495-21496564 [-]

Database links

Mature mmu-miR-199a-5p

Accession MIMAT0000229
Description Mus musculus mmu-miR-199a-5p mature miRNA
Sequence 6 - CCCAGUGUUCAGACUACCUGUUC - 28
Evidence experimental
cloned [5], Illumina [6-7]
Database links
Predicted targets

Mature mmu-miR-199a-3p

Accession MIMAT0000230
Description Mus musculus mmu-miR-199a-3p mature miRNA
Sequence 46 - ACAGUAGUCUGCACAUUGGUUA - 67
Evidence experimental
cloned [1,5], Illumina [6-7]
Database links
Predicted targets

References

  1. PubMed ID: 12554860
    Numerous microRNPs in neuronal cells containing novel microRNAs
    "Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G"
    "RNA (2003) 9:180-186

  2. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  3. PubMed ID: 12554859
    New microRNAs from mouse and human
    "Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T"
    "RNA (2003) 9:175-179

  4. PubMed ID: 12919684
    Embryonic stem cell-specific MicroRNAs
    "Houbaviy HB, Murray MF, Sharp PA"
    "Dev Cell (2003) 5:351-358

  5. PubMed ID: 20215419
    MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
    "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
    "Mol Hum Reprod (2010) 16:463-471

  6. PubMed ID: 20413612
    Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
    "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
    "Genes Dev (2010) 24:992-1009