Stem-loop sequence mmu-mir-191

Accession

MI0000233 (change log)

Symbol

MGI:Mir191

Description

Mus musculus miR-191 stem-loop

Gene family

MIPF0000194; mir-191

Literature search

61 open access papers mention mmu-mir-191
(160 sentences)

Stem-loop

         c          c  aa       uu  -  c 
5' agcggg aacggaaucc aa  gcagcug  gu cu c
   |||||| |||||||||| ||  |||||||  || ||  
3' ucgucc uugcuuuagg uu  cgucgac  ua ga a
         c          -  ca       cu  c  g 

Deep sequencing

4507311 reads, 1.27e+04 reads per million, 107 experiments

Confidence

Annotation confidence: high

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Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].

Genome context

• Coordinates (GRCm38; GCA_000001635.2): chr9: 108568319-108568392 [+]
• Overlapping transcripts:

  antisense

  ENSMUST00000175174 ; Gm24083-201; exon 1

Clustered miRNAs

< 10kb from mmu-mir-191

• mmu-mir-191: chr9: 108568319-108568392 [+]
• mmu-mir-425: chr9: 108568777-108568861 [+]

Database links

• EntrezGene:Mirn191
• MGI:Mir191
• RNAcentral:URS000075C2AC_10090
• miRBase Tracker:MI0000233

Mature sequence mmu-miR-191-5p

• Accession: MIMAT0000221
• Previous IDs: mmu-miR-191
• Sequence: 7 - caacggaaucccaaaagcagcug - 29
• Deep sequencing: 4502528 reads, 107 experiments
• Evidence: experimental; cloned [1-4], Illumina [5-6]
• Database links:
  • RNAcentral:URS00005C2E31_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-191-5p
  • miRDB:mmu-miR-191-5p
  • microrna.org:mmu-miR-191-5p

Mature sequence mmu-miR-191-3p

• Accession: MIMAT0004542
• Previous IDs: mmu-miR-191*
• Sequence: 49 - gcugcacuuggauuucguuccc - 70
• Deep sequencing: 4748 reads, 98 experiments
• Evidence: experimental; cloned [4], Illumina [5-6]
• Database links:
  • RNAcentral:URS000026D6B6_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-191-3p
  • miRDB:mmu-miR-191-3p
  • microrna.org:mmu-miR-191-3p

References

1. PMID:12554859 "New microRNAs from mouse and human" Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T RNA. 9:175-179(2003).
2. PMID:15538371 "A pancreatic islet-specific microRNA regulates insulin secretion" Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M Nature. 432:226-230(2004).
3. PMID:16766679 "Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes" Watanabe T, Takeda A, Tsukiyama T, Mise K, Okuno T, Sasaki H, Minami N, Imai H Genes Dev. 20:1732-1743(2006).
4. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
5. PMID:20215419 "MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing" Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A Mol Hum Reprod. 16:463-471(2010).
6. PMID:20413612 "Mammalian microRNAs: experimental evaluation of novel and previously annotated genes" Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP Genes Dev. 24:992-1009(2010).