Stem-loop sequence mmu-mir-188

Accession

MI0000230 (change log)

Symbol

MGI:Mir188

Description

Mus musculus miR-188 stem-loop

Gene family

MIPF0000113; mir-188

Literature search

36 open access papers mention mmu-mir-188
(256 sentences)

Stem-loop

      ca  uc         gu      -ugag u 
5' ucu  ca  ccuugcaug  ggaggg     c c
   |||  ||  |||||||||  ||||||     | u
3' agg  gu  gggacguac  ccuccc     g c
      ac  uu         ac      caaaa u 

Deep sequencing

7851 reads, 25.5 reads per million, 98 experiments

Confidence

Annotation confidence: high

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Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context

• Coordinates (GRCm38; GCA_000001635.2): chrX: 7247989-7248056 [-]
• Overlapping transcripts:

  sense

  OTTMUST00000039775 ; Clcn5-003; intron 2

  OTTMUST00000039776 ; Clcn5-004; intron 3

  OTTMUST00000039777 ; Clcn5-005; intron 3

  ENSMUST00000128319 ; Clcn5-003; intron 2

  ENSMUST00000115746 ; Clcn5-004; intron 3

  ENSMUST00000132126 ; Clcn5-005; intron 3

Clustered miRNAs

< 10kb from mmu-mir-188

• mmu-mir-532: chrX: 7248402-7248497 [-]
• mmu-mir-188: chrX: 7247989-7248056 [-]
• mmu-mir-362: chrX: 7241982-7242046 [-]
• mmu-mir-501: chrX: 7241243-7241351 [-]

Database links

• EntrezGene:Mirn188
• MGI:Mir188
• RNAcentral:URS000075AB10_10090
• miRBase Tracker:MI0000230

Mature sequence mmu-miR-188-5p

• Accession: MIMAT0000217
• Previous IDs: mmu-miR-188
• Sequence: 6 - caucccuugcaugguggaggg - 26
• Deep sequencing: 6931 reads, 96 experiments
• Evidence: experimental; cloned [1-3], Illumina [4-5]
• Database links:
  • RNAcentral:URS0000083D87_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-188-5p
  • miRDB:mmu-miR-188-5p
  • microrna.org:mmu-miR-188-5p

Mature sequence mmu-miR-188-3p

• Accession: MIMAT0004541
• Sequence: 45 - cucccacaugcaggguuugca - 65
• Deep sequencing: 875 reads, 71 experiments
• Evidence: experimental; cloned [3], Illumina [4-5]
• Database links:
  • RNAcentral:URS000061AB33_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-188-3p
  • miRDB:mmu-miR-188-3p
  • microrna.org:mmu-miR-188-3p

References

1. PMID:12554859 "New microRNAs from mouse and human" Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T RNA. 9:175-179(2003).
2. PMID:15538371 "A pancreatic islet-specific microRNA regulates insulin secretion" Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M Nature. 432:226-230(2004).
3. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
4. PMID:20215419 "MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing" Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A Mol Hum Reprod. 16:463-471(2010).
5. PMID:20413612 "Mammalian microRNAs: experimental evaluation of novel and previously annotated genes" Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP Genes Dev. 24:992-1009(2010).