Stem-loop sequence mmu-mir-181a-2

Accession

MI0000223 (change log)

Previous IDs

mmu-mir-181;mmu-mir-181a

Symbol

MGI:Mir181a-2

Description

Mus musculus miR-181a-2 stem-loop

Gene family

MIPF0000007; mir-181

Literature search

206 open access papers mention mmu-mir-181a-2
(1748 sentences)

Stem-loop

      u  a   u      cu       a    gggauuc 
5' cca gg aca ucaacg  gucggug guuu       a
   ||| || ||| ||||||  ||||||| ||||       a
3' ggu cc ugu aguugc  cagccac caaa       a
      u  a   c      --       -    aaaacaa 

Deep sequencing

5142313 reads, 7.1e+03 reads per million, 107 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Genome context

• Coordinates (GRCm38; GCA_000001635.2): chr2: 38852735-38852810 [+]
• Overlapping transcripts:

  antisense

  OTTMUST00000030867 ; Nr6a1-002; intron 2

  OTTMUST00000029378 ; Nr6a1-001; intron 4

  ENSMUST00000142130 ; Nr6a1-002; intron 2

  ENSMUST00000076275 ; Nr6a1-201; intron 3

  ENSMUST00000112877 ; Nr6a1-001; intron 4

Clustered miRNAs

< 10kb from mmu-mir-181a-2

• mmu-mir-181a-2: chr2: 38852735-38852810 [+]
• mmu-mir-181b-2: chr2: 38853830-38853918 [+]

Database links

• EntrezGene:Mir181a-2
• MGI:Mir181a-2
• RNAcentral:URS000075A833_10090
• miRBase Tracker:MI0000223

Mature sequence mmu-miR-181a-5p

• Accession: MIMAT0000210
• Previous IDs: mmu-miR-181a
• Sequence: 7 - aacauucaacgcugucggugagu - 29
• Deep sequencing: 10154990 reads, 107 experiments
• Evidence: experimental; cloned [2,4], Illumina [5-6]
• Database links:
  • RNAcentral:URS00003DA300_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-181a-5p
  • miRDB:mmu-miR-181a-5p
  • microrna.org:mmu-miR-181a-5p

Mature sequence mmu-miR-181a-2-3p

• Accession: MIMAT0005443
• Previous IDs: mmu-miR-181a-2*
• Sequence: 51 - accaccgaccguugacuguacc - 72
• Deep sequencing: 64988 reads, 98 experiments
• Evidence: experimental; cloned [5], Illumina [6-7]
• Database links:
  • RNAcentral:URS00004E8D28_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-181a-2-3p
  • miRDB:mmu-miR-181a-2-3p
  • microrna.org:mmu-miR-181a-2-3p

References

1. PMID:12554859 "New microRNAs from mouse and human" Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T RNA. 9:175-179(2003).
2. PMID:12624257 "Vertebrate microRNA genes" Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP Science. 299:1540(2003).
3. PMID:15538371 "A pancreatic islet-specific microRNA regulates insulin secretion" Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M Nature. 432:226-230(2004).
4. PMID:15634332 "New human and mouse microRNA genes found by homology search" Weber MJ FEBS J. 272:59-73(2005).
5. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
6. PMID:20215419 "MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing" Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A Mol Hum Reprod. 16:463-471(2010).
7. PMID:20413612 "Mammalian microRNAs: experimental evaluation of novel and previously annotated genes" Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP Genes Dev. 24:992-1009(2010).