Stem-loop sequence mmu-mir-136

Accession

MI0000162 (change log)

Symbol

MGI:Mir136

Description

Mus musculus miR-136 stem-loop

Gene family

MIPF0000099; mir-136

Literature search

24 open access papers mention mmu-mir-136
(148 sentences)

Stem-loop

           c     uuu          uuc 
5' gaggacuc auuug   ugaugaugga   u
   |||||||| |||||   ||||||||||   u
3' cuucugag uaaac   gcuacuaccu   a
           -     ucu          cga 

Deep sequencing

377603 reads, 2.11e+03 reads per million, 86 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].

Genome context

• Coordinates (GRCm38; GCA_000001635.2): chr12: 109595327-109595388 [+]
• Overlapping transcripts:

  sense

  ENSMUST00000093621 ; Mir136-201; exon 1

  antisense

  ENSMUST00000149046 ; Rtl1-201; exon 2

Clustered miRNAs

< 10kb from mmu-mir-136

• mmu-mir-337: chr12: 109585789-109585885 [+]
• mmu-mir-3544: chr12: 109585813-109585873 [-]
• mmu-mir-540: chr12: 109586080-109586146 [+]
• mmu-mir-665: chr12: 109586314-109586407 [+]
• mmu-mir-3070-1: chr12: 109587943-109588031 [+]
• mmu-mir-3070-2: chr12: 109588592-109588680 [+]
• mmu-mir-431: chr12: 109590447-109590537 [+]
• mmu-mir-433: chr12: 109591715-109591838 [+]
• mmu-mir-127: chr12: 109592846-109592915 [+]
• mmu-mir-434: chr12: 109594506-109594599 [+]
• mmu-mir-432: chr12: 109594956-109595030 [+]
• mmu-mir-3071: chr12: 109595318-109595397 [-]
• mmu-mir-136: chr12: 109595327-109595388 [+]

Database links

• EntrezGene:Mir136
• MGI:Mir136
• RNAcentral:URS000075AB4F_10090
• miRBase Tracker:MI0000162

Mature sequence mmu-miR-136-5p

• Accession: MIMAT0000148
• Previous IDs: mmu-miR-136
• Sequence: 5 - acuccauuuguuuugaugaugg - 26
• Deep sequencing: 250265 reads, 82 experiments
• Evidence: experimental; cloned [1-2,4], PCR [3], Illumina [5-6]
• Database links:
  • RNAcentral:URS0000147F3E_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-136-5p
  • miRDB:mmu-miR-136-5p
  • microrna.org:mmu-miR-136-5p

Mature sequence mmu-miR-136-3p

• Accession: MIMAT0004532
• Previous IDs: mmu-miR-136*
• Sequence: 40 - aucaucgucucaaaugagucuu - 61
• Deep sequencing: 127311 reads, 80 experiments
• Evidence: experimental; cloned [4], Illumina [5-6]
• Database links:
  • RNAcentral:URS00005AD224_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-136-3p
  • miRDB:mmu-miR-136-3p
  • microrna.org:mmu-miR-136-3p

References

1. PMID:12007417 "Identification of tissue-specific microRNAs from mouse" Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T Curr Biol. 12:735-739(2002).
2. PMID:15538371 "A pancreatic islet-specific microRNA regulates insulin secretion" Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M Nature. 432:226-230(2004).
3. PMID:15854907 "RNAi-mediated allelic trans-interaction at the imprinted Rtl1/Peg11 locus" Davis E, Caiment F, Tordoir X, Cavaille J, Ferguson-Smith A, Cockett N, Georges M, Charlier C Curr Biol. 15:743-749(2005).
4. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
5. PMID:20215419 "MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing" Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A Mol Hum Reprod. 16:463-471(2010).
6. PMID:20413612 "Mammalian microRNAs: experimental evaluation of novel and previously annotated genes" Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP Genes Dev. 24:992-1009(2010).