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miRBase |
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Stem-loop sequence dme-mir-2b-2 |
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Accession | MI0000120 (change log) | |||||||
Description | Drosophila melanogaster miR-2b-2 stem-loop | |||||||
Gene family | MIPF0000049; mir-2 | |||||||
Literature search |
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29 open access papers mention dme-mir-2b-2 | |||||||
Stem-loop |
a - a --uuu cuu 5' uuguguc uucuucaaag ugguuguga aug gc u ||||||| |||||||||| ||||||||| ||| || 3' agcgcag gaggaguuuc accgacacu uac cg u c g a uuauc uau |
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Deep sequencing |
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Confidence |
Annotation confidence: high
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Comments |
Stark et al. [2] have identified targets for miR-2 in Drosophila using computational prediction followed by experimental validation. miR-2 regulates the proapoptotic genes reaper, grim and sickle, suggesting that it may be involved in the control of apoptosis. |
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Genome context |
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Clustered miRNAs |
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Database links |
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Mature sequence dme-miR-2b-2-5p |
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Accession | MIMAT0020783 |
Sequence |
9 - uucuucaaagugguugugaaaug - 31 |
Deep sequencing | 77914 reads, 49 experiments |
Evidence | not experimental |
Database links |
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Mature sequence dme-miR-2b-3p |
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Accession | MIMAT0000107 |
Previous IDs | dme-miR-2b |
Sequence |
54 - uaucacagccagcuuugaggagc - 76 |
Deep sequencing | 2265994 reads, 49 experiments |
Evidence | experimental; cloned [1,4], Northern [1,3], 454 [5-6], Illumina [6] |
Database links |
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Predicted targets |
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References |
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1 |
PMID:11679670
"Identification of novel genes coding for small expressed RNAs"
Science. 294:853-858(2001).
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2 |
PMID:14691535
"Identification of Drosophila MicroRNA targets"
PLoS Biol. 1:E60(2003).
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3 | |
4 |
PMID:12919683
"The small RNA profile during Drosophila melanogaster development"
Dev Cell. 5:337-350(2003).
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5 |
PMID:17989254
"Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs"
Genome Res. 17:1850-1864(2007).
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6 |
PMID:17989255
"Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes"
Genome Res. 17:1865-1879(2007).
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