Accession
MI0000102
Symbol
HGNC:
MIR100
Description
Homo sapiens
hsa-mir-100 precursor miRNA
Gene family
MIPF0000033;
mir-10
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR100 is a microRNA that has been studied in various contexts. In a study using the Akaike information criteria, the combination of CD146 and CD144 among the extracellular vesicle (EV) membrane proteins, along with MIR100 and miR194, showed high multivariate AUROC values of 0.922 and 0.970, respectively [PMC8821147]. Additionally, an miR-100 expression vector called pBABE MIR100 was constructed using the pBABE-puro retrovirus vector [PMC9873580]. MiR101 was found to regulate Rab1a formation, while MIR100 and miR101 (along with miR15b, miR20a, miR92a, and miR132) were found to play a role in apoptosis by targeting inhibitors of the intrinsic apoptosis pathway [PMC7123062]. These findings highlight the importance of MIR100 in various biological processes and its potential as a therapeutic target or biomarker.
Literature search
205 open access papers mention hsa-mir-100
(1536 sentences)
(1536 sentences)
Sequence
352936
reads,
1446
reads per million, 140 experiments
ccuguugccacaAACCCGUAGAUCCGAACUUGUGguauuaguccgcaCAAGCUUGUAUCUAUAGGUAUGugucuguuagg
((((....((((.(((.((((((.(((.((((((...........)))))).))).)))))).))).)))).....))))
((((....((((.(((.((((((.(((.((((((...........)))))).))).)))))).))).)))).....))))
Structure
-uugc A C C A guau
ccug caca ACC GUAGAU CGA CUUGUG u
|||| |||| ||| |||||| ||| |||||| a
ggau guGU UGG UAUCUA GUU GAACac g
ugucu A A U C gccu
Annotation confidence
High
Do you think this miRNA is real?
Comments
This sequence is localised to chromosome 11 and was named mir-100-11 in reference [1].
Genome context
chr11: 122152229-122152308 [-]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-100
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-100 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-100-5p
| Accession | MIMAT0000098 |
| Description | Homo sapiens hsa-miR-100-5p mature miRNA |
| Sequence | 13 - AACCCGUAGAUCCGAACUUGUG - 34 |
| Evidence |
experimental
cloned [1-3], Illumina [4] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-100-3p
| Accession | MIMAT0004512 |
| Description | Homo sapiens hsa-miR-100-3p mature miRNA |
| Sequence | 48 - CAAGCUUGUAUCUAUAGGUAUG - 69 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
References
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