miRBase entry: hsa-mir-20a

Stem-loop hsa-mir-20a


Accession
MI0000076
Symbol
HGNC: MIR20A
Description
Homo sapiens hsa-mir-20a precursor miRNA
Gene family
MIPF0000001; mir-17

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR20A is a type of microRNA that is involved in mediating MYC and STAT3 dosage compensation through a redundant mechanism [PMC8627999]. In a study investigating regenerative therapy for jawbone atrophy, an atelocollagen-based gene-activated matrix (GAM) containing naked-pDNAs encoding MIR20A was used [PMC7955717]. The expression of MIR20A, along with other microRNAs, was assessed using RT-PCR and shown in Figure 4 [PMC9687337]. SNHG5, an upregulated gene, was found to reduce MIR20A expression and increase the expression of apoptosis proteins BECN1, ATG5, and ATG7 [PMC6912041]. Additionally, SNHG5 could interact with MIR32 to reduce the migration and proliferation effects of SNHG5 on gastric cancer cells [PMC6912041]. In a preliminary experiment using cultured MSCs, it was found that the delivery of MIR20A using an atelocollagen-based GAM had high transfection efficacy without cytotoxicity compared to commercial vectors such as a lentiviral vector [PMC7955717].

Literature search
463 open access papers mention hsa-mir-20a
(1949 sentences)

Sequence

992364 reads, 6826 reads per million, 155 experiments
guagcacUAAAGUGCUUAUAGUGCAGGUAGuguuuaguuaucuACUGCAUUAUGAGCACUUAAAGuacugc
((((.(((.(((((((((((((((((.(((...........))))))))))))))))))))..))).))))

Structure
    c   -A                 G   uguu 
guag acU  AAGUGCUUAUAGUGCAG UAG    u
|||| |||  ||||||||||||||||| |||    a
cguc uGA  UUCACGAGUAUUACGUC Auc    g
    a   AA                 -   uauu 


Annotation confidence High
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Genome context
chr13: 91351065-91351135 [+]
Clustered miRNAs
5 other miRNAs are < 10 kb from hsa-mir-20a
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-20a is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Biological pathways
hsa-mir-20a is involved in one or more biological pathways:
(Source: Reactome)
Biological reactions
hsa-mir-20a is involved in one or more regulation/signalling events:
(Source: Reactome)

Database links

Mature hsa-miR-20a-5p

Accession MIMAT0000075
Description Homo sapiens hsa-miR-20a-5p mature miRNA
Sequence 8 - UAAAGUGCUUAUAGUGCAGGUAG - 30
Evidence experimental
cloned [1,4-7], Northern [1]
Database links
Predicted targets

Mature hsa-miR-20a-3p

Accession MIMAT0004493
Description Homo sapiens hsa-miR-20a-3p mature miRNA
Sequence 44 - ACUGCAUUAUGAGCACUUAAAG - 65
Evidence experimental
cloned [6]
Database links
Predicted targets

References

  1. PubMed ID: 11679670
    Identification of novel genes coding for small expressed RNAs
    "Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T"
    "Science (2001) 294:853-858

  2. PubMed ID: 12554860
    Numerous microRNPs in neuronal cells containing novel microRNAs
    "Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G"
    "RNA (2003) 9:180-186

  3. PubMed ID: 14573789
    Reduced accumulation of specific microRNAs in colorectal neoplasia
    "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
    "Mol Cancer Res (2003) 1:882-891

  4. PubMed ID: 15325244
    Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
    "Kasashima K, Nakamura Y, Kozu T"
    "Biochem Biophys Res Commun (2004) 322:403-410

  5. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  6. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  7. PubMed ID: 15978578
    Identification of human fetal liver miRNAs by a novel method
    "Fu H, Tie Y, Xu C, Zhang Z, Zhu J, Shi Y, Jiang H, Sun Z, Zheng X"
    "FEBS Lett (2005) 579:3849-3854