miRBase entry: hsa-mir-19a

Stem-loop hsa-mir-19a


Accession
MI0000073
Symbol
HGNC: MIR19A
Description
Homo sapiens hsa-mir-19a precursor miRNA
Gene family
MIPF0000011; mir-19

Literature search
313 open access papers mention hsa-mir-19a
(1597 sentences)

Sequence

545193 reads, 9302 reads per million, 118 experiments
gcaguccucuguuAGUUUUGCAUAGUUGCACUACAagaagaauguaguUGUGCAAAUCUAUGCAAAACUGAugguggccugc
((((.((.(((((((((((((((((((((((((((.......))))...))))))..))))))))))))))))).)).))))

Structure
    u  u                 --      ---    ag 
gcag cc cuguuAGUUUUGCAUAG  UUGCAC   UACA  a
|||| || |||||||||||||||||  ||||||   ||||  a
cguc gg gguAGUCAAAACGUAUC  AACGUG   augu  g
    c  u                 UA      Uug    aa 


Annotation confidence High
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Comments
This sequence maps to chromosome 13 and is named miR-19a precursor-13 in reference [2].

Genome context
chr13: 91350891-91350972 [+]
Clustered miRNAs
5 other miRNAs are < 10 kb from hsa-mir-19a
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-19a is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Biological pathways
hsa-mir-19a is involved in one or more biological pathways:
(Source: Reactome)
Biological reactions
hsa-mir-19a is involved in one or more regulation/signalling events:
(Source: Reactome)

Database links

Mature hsa-miR-19a-5p

Accession MIMAT0004490
Description Homo sapiens hsa-miR-19a-5p mature miRNA
Sequence 14 - AGUUUUGCAUAGUUGCACUACA - 35
Evidence experimental
cloned [4]
Database links
Predicted targets

Mature hsa-miR-19a-3p

Accession MIMAT0000073
Description Homo sapiens hsa-miR-19a-3p mature miRNA
Sequence 49 - UGUGCAAAUCUAUGCAAAACUGA - 71
Evidence experimental
cloned [1-5], Northern [1]
Database links
Predicted targets

References

  1. PubMed ID: 11679670
    Identification of novel genes coding for small expressed RNAs
    "Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T"
    "Science (2001) 294:853-858

  2. PubMed ID: 12554860
    Numerous microRNPs in neuronal cells containing novel microRNAs
    "Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G"
    "RNA (2003) 9:180-186

  3. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  4. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  5. PubMed ID: 11914277
    miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
    "Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G"
    "Genes Dev (2002) 16:720-728