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7 publications mentioning hsa-mir-1244-4

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-1244-4. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 31
Further, overexpression of miR-1244 suppressed cell viability and increased apoptosis in the standard NSCLC cell lines by promoting caspase-3 activity, p53 and Bax protein expression, and suppressing myocyte enhancer factor 2D (MEF2D) and cyclin D1 protein expression. [score:11]
logFC p-value B-statistic microRNA 0.98 3.53E-08 9.07 hsa-miR-1244 0.74 2.34E-07 7.34 hsa-miR-494 0.45 6.83E-07 6.34 hsa-miR-1979 0.31 3.97E-06 4.66 hsa-miR-1826 0.77 9.14E-06 3.85 hsa-miR-1281 −0.31 1.13E-05 3.65 hsa-miR-202 −0.37 1.14E-05 3.64 hsa-miR-4284 −0.49 1.70E-05 3.25 hsa-miR-221-star −0.89 6.51E-05 1.94 hsa-miR-3172 −0.63 9.48E-05 1.57 hsa-miR-548a-3p −0.43 1. 02E-04 1.49 hsa-miR-1272 −0.34 1.29E-04 1.27 hsa-miR-15a −0.40 1.59E-04 1.06 hsa-miR-3152 −0.22 2.56E-04 0.59 hsa-miR-142–5p 0.24 3.03E-04 0.43 hsa-miR-4270 −0.29 3.27E-04 0.35 hsa-miR-1910 −0.42 3.29E-04 0.35 hsa-miR-34a-star −0.18 3.78E-04 0.21 hsa-miR-381 −0.30 4.10E-04 0.13 hsa-miR-450b-5p 0.30 4.34E-04 0.08 hsa-miR-1469 We also looked for differentially expressed miRNAs (BH adjusted p < 0.05) that may target differentially expressed mRNAs (BH adjusted p < 0.05). [score:7]
Specifically, the expression levels of our top hit, hsa-miR-1244, have been shown to decrease in A549 and NCI-H522 cells, as well as patient-derived tumor samples after cisplatin treatment, with the overall survival times of cisplatin -treated patients being longer for those who had high miR-1244 expression [37]. [score:5]
In a separate study [2], miR-1244 was again associated with cisplatin efficacy, as both miR-1244 and miR-589 were significantly downregulated in cisplatin-resistant A549 cells (A549/DDP) when compared to the parental cell line, and transfection of A549/DDP with either miRNA markedly increased sensitivity to cisplatin, indicating that miR-1244 has important tumor suppressive functions that may be vital in the treatment of NSCLC. [score:5]
Interestingly, the second highest differentially expressed miRNA in our study, hsa-miR-494, has also been associated with NSCLC cell survival, but contrary to miR-1244, the miRNA was demonstrated to have carcinogenic potential [38]. [score:3]
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2
[+] score: 16
We observed a significant overexpression of miR-21, miR-96, miR-135, miR-141, miR-182, miR-205, miR-429, miR-520b (all p<0.001) in UUTUC; the microRNAs miR-10a (p = 0.012) and miR-200b (p = 0.006) showed a distinct trend towards upregulation, whereas miR-1244 (p = 0.600) was similar in normal and malignant tissue. [score:6]
The expression of eleven microRNAs (miR-10a, miR-21, miR-96, miR-135, miR-141, miR-182, miR-200b, miR-205, miR-429, miR-520b, miR-1244) formerly shown to be upregulated in urothelial bladder cancer were studied in corresponding normal and cancerous tissue samples of patients undergoing nephroureterectomy for UUTUC. [score:6]
In order to investigate the role of microRNAs as non-invasive biomarkers in patients with UUTUC, the expression of eleven microRNAs (miR-10a, miR-21, miR-96, miR-135, miR-141, miR-182, miR-200b, miR-205, miR-429, miR-520b, miR-1244) earlier shown to be upregulated in urothelial cancer of the bladder [13– 20], was analyzed [11] in corresponding normal ureter and UUTUC tissue. [score:4]
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3
[+] score: 10
Furthermore, MEF2D regulate miR-1244 by directly binding to its promoter and this molecular regulatory loop could be a target for lung carcinoma treatment [80]. [score:6]
Similarly, miR-122 and miR-1244 negatively regulate MEF2D expression in hepatocellular carcinoma and lung cancer cells, respectively [39, 80]. [score:4]
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4
[+] score: 5
Altogether, 20 high confidence expressed miRNA were identified and the presence of miR1244 and miR3648/3687 precursors in the EVs was further validated by PCR (Supplementary Fig.   S5). [score:3]
Indeed, EVs of W8B2 [+] CSCs were found enriched with miRNA precursors and miRNAs known to regulate cell survival (miR-3615 and miR-6087), angiogenesis (miR-1244) and cell proliferation (miR-3687, miR-1244, miR-3615 and miR-6087), and these could be further processed into mature miRNAs in the recipient cells and responsible for the biological activities of EVs reported here (Fig.   3D–G). [score:2]
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5
[+] score: 5
Focusing on the endothelium, microarrays were recently used to reveal that physiological (1 nmol/L) estradiol concentrations induce changes in the miRNA expression profile of endothelial cells [106]; among these, the miRNAs with the strongest differential expression were miR-30b-5p, miR-487a-5p, miR-4710, miR-501-3p, miR-378h, and miR-1244. [score:5]
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6
[+] score: 3
For instance, in two microRNA families, hsa-mir-1233 and hsa-mir-1244 (Figure 3, Additional file 7), we can clearly see that most of the microRNA paralogs had nearly identical mature sequences, while others demonstrate dissimilar features. [score:1]
Potential novel mechanism of emergence for microRNA family hsa-mir-1244. [score:1]
Click here for file Potential novel mechanism of emergence for microRNA family hsa-mir-1244. [score:1]
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7
[+] score: 1
In this study, we used time-lapse video microscopy to observe cell movement in the scratch-wound assay, validated the results using the transwell migration assay, and identified the migration-suppressing miRNA (miR-134) and migration-facilitating miRNAs (miR-1247, miR-1244, miR-146b-3p, miR-1471, miR-188-3p, miR-661, miR-891a, miR-891b and miR-767-5P) in SK-HEP-1 cells. [score:1]
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