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3 publications mentioning ssa-mir-146a-2

Open access articles that are associated with the species Salmo salar and mention the gene name mir-146a-2. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 41
The distribution of miRNAs that were predicted to target multiple genes showed that 13 of the miRNAs; ssa-miR-462a-3p, ssa-miR-731-5p, ssa-miR-146b-5p, ssa-miR-146a-3p, ssa-miR-146a-3-3p, ssa-miR-181c-5p, ssa-miR-223-5p, ssa-miR-734-3p, ssa-miR-21a-2-3p, ssa-miR-21b-3p, ssa-miR-1338-3p, ssa-miR-155-5p and ssa-miR-2188-3p were predicted to target several genes. [score:5]
Other conserved miRNA genes, like miRNA-146, miRNA-181 and miRNA-155 are also known to be INF-regulated in vertebrates with increased expression upon stimulation [11]. [score:4]
Fig. 4 Shows the relative changes in expression for ssa-miR-21a-1-3p, ssa-miR-21b-3p, ssa-miR-21a-2-3p, ssa-miR-1338-3p, ssa-miR-7132-5p and ssa-miR-2188-3p at all time points for each of the SAV groups Ten of the 16 DE miRNAs (ssa-miR462a-5p and 3p, ssa-miR-731-5p and 3p, ssa-miR-146a-3p, ssa-miR-146b-5p, ssa-miR-223-5p, ssa-miR-181c-5p, ssa-miR-155-5p and ssa-7132-3p) showed increases across week 2, 3 and 4 poc in all SAV groups. [score:3]
The 5p and 3p mature miRNAs of ssa-miRNA-462a and ssa-miRNA-731-5p genes showed very similar patterns (see Additional file 3) and only the 5p mature miRNAs were included in Fig.   3 The expressions were significantly different from the controls at week 3 and 4 poc in all three SAV groups in seven miRNAs; ssa-miR462a-5p, ssa-miR462a-3p, ssa-miR-731-5p, ssa-miR-731-3p, ssa-miR-146a-3p ssa-miR-223-5p and ssa-7132-3p. [score:3]
The eighteen DE miRNAs that revealed increased expression were ssa-miR-462a-5p and 3p, ssa-miR-462b-5p, ssa-miR-731-5p and 3p, ssa-miR-146b-5p, ssa-miR-146a-3p, ssa-miR-146a-3-3p, ssa-miR-21a-1-3p, ssa-miR-21a-2-3p, ssa-miR-21b-3p, ssa-miR-181c-5p, ssa-miR-223-5p, ssa-miR-1338-3p, ssa-miR-155-5p, ssa-miR-92a-3-5p, ssa-miR-7132-5p and 3p. [score:3]
Fig. 4 Shows the relative changes in expression for ssa-miR-21a-1-3p, ssa-miR-21b-3p, ssa-miR-21a-2-3p, ssa-miR-1338-3p, ssa-miR-7132-5p and ssa-miR-2188-3p at all time points for each of the SAV groups Ten of the 16 DE miRNAs (ssa-miR462a-5p and 3p, ssa-miR-731-5p and 3p, ssa-miR-146a-3p, ssa-miR-146b-5p, ssa-miR-223-5p, ssa-miR-181c-5p, ssa-miR-155-5p and ssa-7132-3p) showed increases across week 2, 3 and 4 poc in all SAV groups. [score:3]
A comparison showed that in the four miRNAs ssa-miR-731-5p, ssa-miR-146a-3p, ssa-miR-146b-5p and ssa-miR223-5p, there was a significant difference in expression in the SAV3-i6 group versus both the SAV2-i1 and SAV3-i4 groups at week 4 poc. [score:3]
The 5p and 3p mature miRNAs of ssa-miRNA-462a and ssa-miRNA-731-5p genes showed very similar patterns (see Additional file 3) and only the 5p mature miRNAs were included in Fig.   3 The expressions were significantly different from the controls at week 3 and 4 poc in all three SAV groups in seven miRNAs; ssa-miR462a-5p, ssa-miR462a-3p, ssa-miR-731-5p, ssa-miR-731-3p, ssa-miR-146a-3p ssa-miR-223-5p and ssa-7132-3p. [score:3]
Fig. 3Shows the relative changes in miRNA expression at all time points for each of the SAV groups for the following miRNAs: ssa-miR-462a-5p, ssa-miR-731-5p, ssa-miR-146a-3p, ssa-miR-146b-5p, ssa-miR-223-5p, ssa-miR-181c-5p, ssa-miR-155-5p and ssa-miR-7132-3p. [score:3]
The conserved miRNAs miR-146, miR-155 and miR-223 have been predicted to target important immune system response genes in other vertebrates (e. g. IRAK1, TRAF6, SOCS1 and STAT3) [40– 43, 45]. [score:3]
The same Atlantic salmon miRNAs (ssa-miR-146, ssa-miR-155 and ssa-miR-223) did not reveal any target site matches to the Atlantic salmon orthologs of these genes (Additional file 4). [score:3]
The expression of these miRNAs (ssa-miR-462a-5p and 3p, ssa-miR-731-5p and 3p, ssa-miR-146a-3p, ssa-miR-146b-5p, ssa-miR223-5p, ssa-miR-155-5p, ssa-miR-181c-5p and ssa-miR7132-3p) were higher in the fish infected with SAV3-i6 (Fig.   3, Additional file 3) than in the other SAV3 isolate (SAV3-i4) at week 4 poc. [score:3]
Ten of the 16 DE miRNAs (ssa-miR462a-5p and 3p, ssa-miR-731-5p and 3p, ssa-miR-146a-3p, ssa-miR-146b-5p, ssa-miR-223-5p, ssa-miR-181c-5p, ssa-miR-155-5p and ssa-7132-3p) showed increases across week 2, 3 and 4 poc in all SAV groups. [score:1]
Two miRNAs were not included in this validation (ssa-miR-462b-5p and ssa-miR-146a-3-3p) as two other miRNAs (ssa-miR-462a-5p and ssa-miR-146a-3p) with very similar mature sequences from the same miRNA families were included. [score:1]
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2
[+] score: 12
Other miRNAs from this paper: hsa-mir-21, hsa-mir-23a, hsa-mir-25, hsa-mir-26a-1, hsa-mir-26b, hsa-mir-30a, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-192, hsa-mir-148a, hsa-mir-30c-2, hsa-mir-30d, hsa-mir-10a, hsa-mir-10b, hsa-mir-34a, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-187, hsa-mir-181a-1, hsa-mir-221, hsa-mir-30b, hsa-mir-122, hsa-mir-125b-1, hsa-mir-152, hsa-mir-125b-2, hsa-mir-146a, hsa-mir-193a, hsa-mir-181b-2, hsa-mir-30c-1, hsa-mir-34b, hsa-mir-34c, hsa-mir-30e, hsa-mir-26a-2, hsa-mir-148b, hsa-mir-193b, hsa-mir-181d, hsa-mir-92b, hsa-mir-454, ssa-mir-10a-1, ssa-mir-10a-2, ssa-mir-10b-1, ssa-mir-10b-2, ssa-mir-10b-3, ssa-mir-10b-4, ssa-mir-10d-1, ssa-mir-10d-2, ssa-mir-122-1, ssa-mir-122-2, ssa-mir-125b-1, ssa-mir-125b-2, ssa-mir-125b-3, ssa-mir-146a-1, ssa-mir-146a-3, ssa-mir-148a, ssa-mir-148b, ssa-mir-152, ssa-mir-16a-1, ssa-mir-16a-2, ssa-mir-181a-1, ssa-mir-181a-2, ssa-mir-181a-3, ssa-mir-181a-4, ssa-mir-181a-5, ssa-mir-181b, ssa-mir-181c, ssa-mir-192a-1, ssa-mir-192a-2, ssa-mir-192b, ssa-mir-193, ssa-mir-21a-1, ssa-mir-21a-2, ssa-mir-21b, ssa-mir-221, ssa-mir-23a-3, ssa-mir-23a-4, ssa-mir-23a-1, ssa-mir-23a-2, ssa-mir-25-1, ssa-mir-25-2, ssa-mir-25-3, ssa-mir-26a-1, ssa-mir-26a-2, ssa-mir-26a-3, ssa-mir-26a-4, ssa-mir-26a-5, ssa-mir-26a-6, ssa-mir-26b, ssa-mir-26d, ssa-mir-30a-3, ssa-mir-30a-4, ssa-mir-30a-1, ssa-mir-30a-2, ssa-mir-30b, ssa-mir-30c-1, ssa-mir-30c-2, ssa-mir-30d-1, ssa-mir-30d-2, ssa-mir-30e-1, ssa-mir-30e-2, ssa-mir-30e-3, ssa-mir-454, ssa-mir-462a, ssa-mir-92a-1, ssa-mir-92a-2, ssa-mir-92a-3, ssa-mir-92a-4, ssa-mir-92b
With regards to the importance of the MIR146a and MIR148a in regulating key cellular processes in the diseased liver state (Fig 5B), we believe that the modulation of the miRNA expression in the liver of whitefish after 14 and 28 days of the exposure may be linked to the chronic effects of MC-LR exposure [39] and the potential activity of the cyanotoxin as a tumor promoter [1]. [score:6]
We focused on 6 aberrantly expressed miRNAs found in our study (MiR122, MiR92a(b), MiR146a, MiR148a, MiR221) for which contributions to a disease state of liver in humans have been proven. [score:5]
MIR146a in particular has gained importance as the modulator of differentiation and function of cells of the innate and adaptive immune system [72]. [score:1]
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3
[+] score: 2
Additional studies have also established functions for specific miRNAs in regulating spermatogenesis, including the miR-17-92 family [23], the testis-enriched and sexually-dimorphic miR-140 [24], the retinoic acid (RA) -induced miR-146, and the clustered miR-221 and miR-222 [25– 27]. [score:2]
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