sort by

5 publications mentioning hsa-mir-4508

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-4508. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 25
The Tukey post hoc test revealed that in comparison to the mock-infected cells, miR-4508, miR-3960, miR-3614-5p, miR-181a-3p are upregulated in DENV-challenged cells; miR-4508, miR-3960, and miR-4301 are upregulated in the sorted DENV-plus cell population; and miR-4508, miR-3960, miR-3614-5p and miR-181a-3p are upregulated in the DENV-neg population. [score:10]
The results show a 6.9- and 6.1-fold change in miR-4508 and miR-3960 expression levels in DENV-plus cells over mock-infected cells (Fig 2A). [score:3]
To validate the sequencing results, we next analyzed the expression level of the miRNAs with the highest changes (miR-4508 and miR-3960) by real-time PCR. [score:3]
For example, an increased expression of miR-4508 and miR-4301 has been observed in several cancer types [44– 47] and it was previously reported that miR-3960 can be used as a marker for type 2 diabetes [48]. [score:3]
0005981.g002 Fig 2 (A) miR-3960 and miR-4508 expression was determined by real-time PCR using specific primers for the mature form of the miRNAs. [score:2]
At 24 h post-seeding, cells were transfected with 1.5μl of lipofectamine RNAi/Max (Invitrogen) and a final concentration of 10mM of miRNAs mimics (Ambion, cat 4464066; miR-3960 (ID: MC22178), miR-4508 (ID: MC21571), miR-4301 (ID: MC17762), miR-181a (ID: MC10381) and miR-3614-5p (ID: MC20080)). [score:1]
In DENV-neg cells, a 1.8 fold change was seen for miR-4508 and no change in miR-3960 was observed when related to mock-infected cells (Fig 2A). [score:1]
Effect of miR-181a, miR-4301, miR-3960 and miR-4508 on DENV infection of Huh7 cells. [score:1]
Unexpectedly, neither the percentage of infection nor the viral titers were affected by miR-3960, miR-4508, miR-4301 and miR-181a in Huh7 cells following infection at MOIs 1, 5, and 10 (Fig 3). [score:1]
[1 to 20 of 9 sentences]
2
[+] score: 3
Among these detected miRNAs, miR-1268a, miR-3648, miR-3687, miR-4508, and miR-6724 were originated in rDNA containing chromosomes, Chr 15, Chr 21, Chr 21, Chr 15, and Chr 21, respectively. [score:1]
Subsequently, seventeen RNA alignments identical to human mature miRNAs, namely, miR-663a, miR-663b-3p, miR-1268a, miR-1268b, miR-1275, miR-3648, miR-3656-3p, miR-3687-3p, miR-4417, miR-4466, miR-4488, miR-4492-3p, miR-4508, miR-4516, miR-4532, miR-6087, and miR-6724, were detected from the human rRNA sequences (Table 1). [score:1]
Other three pre-rmiRNAs, pre-rmiR-3656, pre-rmiR-4417, pre-rmiR-4466, and pre-rmiR-4508 also showed high similarity in secondary structures to pre-miR-3656, pre-miR-4417, pre-miR-4466, and pre-miR-4508, respectively, although their precursor sequences showed low similarities to canonical ones (Supplemental Figure  2A). [score:1]
[1 to 20 of 3 sentences]
3
[+] score: 2
Hsa-miR-1246, hsa-miR-4488, hsa-miR-4508, hsa-miR-4492 and hsa-miR-4516 were identified as the 5 most abundant miRNA types in exosomes derived from hNSC producers and had the highest ratio of exosomal to cellular miRNA abundance. [score:1]
Hsa-miR-1246, hsa-miR-4488, hsa-miR-4508, hsa-miR-4492 and hsa-miR-4516 were identified as the 5 most exosomal enriched miRNAs (Fig 2C). [score:1]
[1 to 20 of 2 sentences]
4
[+] score: 2
Among others, we observed > twofold decreased expression of miR-3175, miR-720, miR-4508 and miR-4492 in tubulovillous adenoma compared  to tubular adenoma samples. [score:2]
[1 to 20 of 1 sentences]
5
[+] score: 1
01 Down 4.40E-07 hsa-miR-4488 5.95 Up 4.10E-35 hsa-miR-1269b −6.74 Down 3.15E-06 hsa-miR-296-5p 5.84 Up 3.88E-78 hsa-miR-3674 −6.74 Down 3.16E-06 hsa-miR-4454 5.19 Up 3.07E-85 hsa-miR-3910 −6.74 Down 3.17E-06 hsa-miR-4687-3p 4.37 Up 8.32E-26 hsa-miR-642a-3p −6.74 Down 5.10E-32 hsa-miR-3654 3.38 Up 1.21E-25 hsa-miR-486-5p −6.46 Down 2.81E-100 hsa-miR-577 2.94 Up 8.64E-05 hsa-miR-203 −6.30 Down 3.19E-89 hsa-miR-4508 2.9 Up 5.94E-06 hsa-miR-1277-3p −6.16 Down 3.01E-41 hsa-miR-3687 2.49 Up 2.04E-05 hsa-miR-1277-5p −5. [score:1]
[1 to 20 of 1 sentences]